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Separation of Basic Drug Compounds (Jan 2023)
Mobile phase pH is a powerful tool for separating neutral forms of amines or other organic bases. See how Hamilton used PRP-C18 to separate six basic drug compounds.
Determining PAHs in Soil Matrices
A method for determining 16 PAHs in soil matrices using the Extreva Ase system, the Trace 1310 Gas Chromatograph, and the ISQ 7000 single quadrupole mass spectrometer.
Extraction of VOCs in Aromatherapy Oil
This application note demonstrates a quick temperature ramp technique to improve the focusing of VOCs without using a secondary focusing trap.
Determination of PAHs in Soils Using Thermo Scientific EXTREVA ASE
Method for the determination of 16 PAHs in soil matrices using the EXTREVA ASE system and TRACE 1310 Gas Chromatograph and ISQ 7000 Single Quadrupole Mass Spectrometer
Sample Prep and LC–MS Analysis of PFAS Compounds in EPA 533
This application note demonstrates the extraction of 25 PFAS analytes from drinking water using Supelclean™ ENVI-WAX™ SPE as described in regulated method EPA 533.
Advances in Mass Spectrometry Instrument Intelligence
Detecting and Analyzing PFAS in Various Matrices
When detecting and analyzing PFAS, the greatest hurdles lie in the various matrices in which PFAS are found. Custom methods and extensive expertise help to solve these issues.
PFAS Analysis: Challenges in Various Matrices
Determination of Total Fluorine Using CIC
Learn how the non-targeted analysis of total fluorine can be done using Metrohm combustion ion chromatography.
Application Note: Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC/MS-Based Metabolomics
Application Note: Determination of Heavy Metals and Trace Elements in Alternative Meats Per EAM 4.7 Method for ICP-MS
Application Note: LC/Q-TOF Analysis and Nontargeted Chemometric Profiling of Meats and Plant-Based Alternatives
Poster: Alleviating Shedding of Particulate Matter from SEC Resins for Improved Online Light Scattering and Mass Spectrometry Analysis of Biomolecules
Poster: Characterization of Adeno-Associated Virus Vectors by Size Exclusion Chromatography-Multi-Angle Light Scattering Technology
Benzodiazepine Metabolites by Reversed-Phase HPLC
Although the majority of benzodiazepines metabolize to a single compound, oxazepam, other metabolites can be detected by liquid chromatography.
Separation of Basic Drug Compounds
In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.
Raffinose Family of Oligosaccharides by Cation Exchange
The Raffinose Family of Oligosaccharides (RFO) is comprised of low molecular weight non-reducing sugars. Analysis of these compounds is not easily done unless using HC-75.
Pick Your Poison. Isolation of Paclitaxel
Paclitaxel originates from the Pacific Yew tree. The isolation of paclitaxel from its major impurities is shown with the use of Hamilton’s PRP-1 (5 µm) HPLC column.
Separation of Fat Soluble Vitamin K Congeners in Under 6 Min
The fast simple method developed by Hamilton Company using the PRP-C18 column allows for simple, efficient identification of the whole vitamin series (K2, K3, and K4).
Oligonucleotide Purification by Reversed-Phase Ion Pairing
A Hamilton PRP-C18 (5 μm) HPLC column was used for purification of three oligonucleotides. Analysis of a 21-mer, 22-mer, and 23-mer of similar structure was evaluated.
LC-MS Analysis of 33 PFAS Compounds in 5 minutes
The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.
Identification and Quantification of Different Cannabinoids in Cannabis Sativa (Dec 2022)
The presented methods are suitable for the quantification of THC and THCA (and other cannabinoids) in Cannabis sativa and to check THC-free cannabis for compliance.
Accurate Mass Library for Natural Products Based on Compounds Identified in Hemp Oil Using High-Resolution GC/Q-TOF
Dynamic MRM/Scan Mode: Adding More Confidence to Sensitive Quantitation in Complex Foods by Triple Quadrupole GC/MS
Analysis of Semivolatile Organic Compounds with US EPA 8270E Using the Agilent 7000E Triple Quadrupole GC/MS
Five Keys to Unlock Maximum Performance in the Analysis of Over 200 Pesticides in Challenging Food Matrices Using GC–MS
Extraction of Novel Synthetic 2-Benzylbenzimidazole Opioid Compounds "Nitazenes" (Dec 2022)
This application note introduces a simple targeted extraction method for the analysis of nine nitazene compounds from urine and blood using the Clean Screen® DAU column.
Volatile Organic Compounds Analysis in Drinking Water with Headspace GC/MSD Using Hydrogen Carrier Gas and HydroInert Source
Analysis of Semivolatile Organic Compounds Using Hydrogen Carrier Gas and HydroInert Ion Source by Gas Chromatography/Mass Spectrometry
Separation of 12 Nucleosides on Hamilton PRP-1 Column (Dec 2022)
The primary nucleosides encompass a broad array of biological functions associated with RNA, particularly after configuration into multidimensional conformations.