Application Notes

This app note demonstrates a comprehensive software workflow for non-targeted analysis of per- and polyfluoroalkyl substances by high-resolution mass spectrometry.

In this app note, we evaluate the performance of the novel Orbitrap Astral mass spectrometer for plasma proteomics using 4 of the most common plasma sample prep methods

Clinical Research: Streamlined workflow and minimum up-front development efforts using the first commercial ready-to-use kits for quantitative analysis of mAbs

Comparison of analytical methods for quantification of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 on a Thermo Scientific™ TSQ Altis™ MD mass spectrometer

This tech note presents a low-input proteomics sample workflow using the Pierce HeLa protein digest standard in nanogram and picogram loads on the Orbitrap Astral mass spectrometer

This application note discusses an advanced sensitive, reproducible and efficient single-cell measurement and sample throughput workflow platform.

Thermo Scientific ProPac 3R SAX columns provide excellent separation of Protein G charge variants using a salt gradient. Its unique design delivers high resolution, robust performance, and excellent reproducibility needed for charge variant analysis of proteins.

Designed with bio-inert materials, the new Thermo Scientific ProPac 3R columns support the delivery of reproducible, high resolution and robust strong anion and strong cation exchange chromatography separations for protein and monoclonal antibody analysis.

With advances in the technologies used in LC-MS-based proteomics workflows, sensitive, reproducible, and efficient single-cell proteomics is now possible. Learn about these advances and how they work in concert to maximize the combination of protein and peptide identifications and sample throughput.

ProPac 3R SAX columns will provide high resolution, robust performance and unrivalled lot-to-lot reproducibility needed for these applications.

Thermo Scientific ProPac 3R SCX columns provide excellent separation of mAb and associated charge variants using a salt gradient to give high-resolution, robust performance and excellent reproducibility

Thermo Scientific ProPac 3R SCX columns, combined with Thermo Scientific CX-1 pH gradient buffers, provide fast, reproducible, and ultra-high resolution for monoclonal antibodies and associated charge variants.

Nine structurally diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient.

Chemically resistant resin bed allows for a wide base of mobile phase choices with excellent anion separation

This focuses on the identification of polyphenolic catechin compounds for health and industrial quantification and quality control of tea products.

The isolation of the diterpenoid, paclitaxel, from its major impurities is shown with the use of Hamilton’s PRP-1 (5 µm) HPLC column.

A reversed-phase HPLC method was developed for separation of five steroid hormones with partition coefficients ranging from 1.47 (cortisone) to 4.5 (pregnenolone).

In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.

Isolation of six common allergens can be achieved by utilizing reversed-phase HPLC using an alkaline eluent.

The identification benzodiazepine metabolites can be highly valuable in detecting abuse. Metabolites of oxazepam are found containing both hydroxyl and glucuronides.

This application note describes how Dow AgroSciences created efficiency in method development by incorporating method development software into their best practices.

Outlines an extraction procedure and an optional fluorenylmethyloxycarbonyl chloride derivatization step to allow for the analysis of glyphosate on a C18 column.

Improved and universal subunits LC–MS analysis of multiple classes of monoclonal antibodies using in-line electrochemical reduction  

Daicel Chiral Technologies' unique HPLC and SFC chiral stationary phases are capable of separating the most challenging compounds, like the atropisomers of Sotorasib.

Smart-ramped pyrolysis-GC–MS analysis of forensic samples such as paint, adhesive tape, and mascara gives maximum info in a single run without method development.

Smart-ramped pyrolysis-GC–MS analysis of nylon material in consumer products, food packaging, and clothing generates info in one run without method development.