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Measuring Organic Acids and Inorganic Anions with IC-MS
August 18th 2023Ion chromatography and mass spectroscopy can be combined to create a powerful analytical technique. Check out this white paper to learn how IC-MS was used for the straightforward ID and quantification of organic acids and inorganic anions in one run.
Ready for combat: Fighting against lab space shortage
August 16th 2023The UK's life sciences prowess and ambition to become a 'science superpower' rely on the continuous supply of highly specialised lab space. However, we are currently facing a national challenge, with lab space critically low in abundance. The question is, how do we fix this problem?
Stand out from the crowd: The ultimate guide to custom laboratory space
August 16th 2023There is an ever increasing demand for bespoke laboratory space for science and technology companies like yours due to the individual nature of your research and operations. Bruntwood SciTech makes acquiring custom laboratory space easy, reliable and affordable, so your business can form, scale and grow.
ASMS 2023 HDX-MS with Inline Electrochemical Reduction of Disulfide Bonds: State-of-the-Art
August 2nd 2023HDX-MS with online EC reduction enables successful epitope mapping of mAbs to challenging S-S bonded protein targets, e.g., VEGF. The biophysical characterization of VHH-IR4, a BBB-crossing single-domain antibody (sdAb) is described for the first time and was only possible using EC reduction.
ASMS 2023 SweetSep™ a New HPLC Column for the Fast Analysis of Carbohydrates and Glycans by LC-MS
August 2nd 2023High-Performance Anion Exchange Chromatography in combination with PAD or MS detection is the method of choice for the analysis of all classes of carbohydrates including glycans. A novel anion-exchange stationary phase SweetSep™ has been developed that allows for fast and high resolution separation.
HPLC 2023 Analysis of Carbohydrates in Food Using a New Anion Exchange Column SweetSep™ AEX200
August 2nd 2023The AEX200 column demonstrate (a) fast separation of mono-, di- and trisaccharides in various food sample matrices, (b)sensitive quantification of carbohydrates down to femtomole levels, (c) high-resolution separation of high-molecular weight oligosaccharides with a degree of polymerization up DP of 60.
HPLC 2023 New Anion-Exchange Columns for the Analysis of N-Glycans Using HPAEC-PAD/MS
August 2nd 2023Separation of all 6 glycan monosaccharides of interest and 2-Deoxy-D-Glucose (glycosylation inhibitor) was achieved within 7 minutes using the new SweetSep™ AEX20 column under isocratic elution conditions. Furthermore, profiling of released N-glycans from glycoproteins without the need for sample derivatization is shown using HPAEC-MS.
Increase Lab Productivity Anytime, From Anywhere
July 31st 2023The waters_connect™ System Monitoring is the latest innovation in lab management, providing real-time information for all Empower-controlled chromatography systems via the waters_connect cloud platform. Coordinating laboratory work and responding dynamically to changing priorities has never been easier.
Adaption of Retention Models to Allow Optimization of Peptide and Protein Separations
July 25th 2023This application note discusses the use of the LC Simulator module to accurately model retention and peak width of proteins and peptides in analytical scale reversed phase and ion exchange chromatography.
Merck Simplifies and Streamlines Method Development with In Silico Modeling
July 25th 2023Retention modeling has proven to be a successful technique in accelerating method development and optimization. This case study gives a more detailed insight into how scientists at Merck use computer-assisted modeling to develop robust methods faster.