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High Quality, Primary Pharmaceutical Reference Standards for Better and Safer Medicines
May 9th 2023It is essential to understand the pharmacokinetic profiles and toxicological concerns associated with substances/compounds produced into reference standards trusted for analytical testing and development of high quality pharmaceutical therapies.
Syft Tracer: The Next Generation of Volatile Impurities Analysis for Enhanced Workflows (May 2023)
May 1st 2023This app note introduces the next generation of SIFT-MS that revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility. Learn about how eliminates the hassles associated with chromatography and outpaces traditional methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.
Head to Head Comparison of Class 2A And 2B Residual Solvents Analysis Using Sift-MS And GC-FID
May 1st 2023This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).
Headspace-SIFT-MS: Flexibility That Revolutionizes Workflows for Diverse Samples
May 1st 2023The characteristic flexibility, stability, high throughput, and fast time to report analytical results of the Syft Tracer next-generation SIFT-MS instrument apply across multiple headspace approaches for diverse matrices. This application note briefly summarizes the use of (1) dissolution, (2) multiple headspace extraction (MHE), and (3) the method of standard additions, then provides a guide for identifying the appropriate headspace approach for various matrices.
Quick, Clean, and Complete Peptide Mapping for mAbs (Apr 2023)
April 21st 2023Complete and clean trypsin digestion can be achieved with an enzyme that provides a balance of low levels of missed cleavage, non-specific cleavage, and trypsin autolysis. RapiZyme, a next generation trypsin, offers efficiency and reproducibility.