Application Notes

Time to results can be significantly reduced with the use of RapidFire high-throughput mass spectrometry (MS). With this technique, a lab’s next great innovation can be brought from conception to reality in a timely and efficient manner.

This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.

Explore Metrohm's Profiler-F Analyzer and its non-targeted screening of organically bound fluorine which gives a better overall picture of potential PFAS contaminants

Analysis of volatile organics in soils using the CDS 8500 Automated Purge and Trap System.

This application note demonstrates the performance of multi-detector asymmetrical flow field-flow fractionation for the characterization of macromolecules in beer.

Lipid nanoparticles (LNPs) are effective non-viral carriers, which are widely used as delivery vehicles for gene-based drugs such as messenger RNA (mRNA). To mitigate safety risks and ensure product efficacy, it is important to comprehensively characterize the lipids used for LNPs and their related impurities, as well as the mRNA integrity, purity and its critical quality attributes (CQAs).

Helium supply is unreliable. Prices are increasing, supply is decreasing, and the need for an alternative carrier gas is growing. So does your lab reduce its helium consumption or switch to an alternative carrier gas?

An introduction to microchamber sampling for the rapid screening of chemical emissions from construction materials and consumer products

This application note shows the robust, reproducible analysis of trace VOCs in hydrogen fuel by TD–GC–MS/SCD.

Theory and practice of using axial and radial samplers for passive (diffusive) monitoring of VOCs in air

It is essential to understand the pharmacokinetic profiles and toxicological concerns associated with substances/compounds produced into reference standards trusted for analytical testing and development of high quality pharmaceutical therapies.

Personal exposure testing of nitrous oxide can be done via passive and breath sampling using Markes’ Bio-VOC and TD–GC.

Advice on which sorbent to use for pumped (diffusive) tube monitoring of various vapour-phase organics; suggests parameters for conditioning and storing packed tubes.

How TD benefits a wide range of industrial emissions testing applications, offering compatibility with both whole-air/gas containers and sorbent tubes

Demonstrating the efficient use of online and off-line trace-level analysis of thermally labile sulfur compounds by TD–GC; used in air monitoring and industry.

A Hamilton PRP-C18 (5 μm) HPLC column was used for purifying three oligonucleotides. Analysis of a 21mer, 22mer, and 23mer of similar structure were evaluated.

Sulfide compounds found in garlic oils are used in therapeutics and prophylaxis of certain cancers, and are prevalent in cell health.

Identification and quantification of the Raffinose Family of Oligosaccharides allows a more thorough understanding of an individual’s gut health.

Garlic has been found to exhibit a multitude of proliferative health benefits in the realm of cardiac events.

Isolation of capsaicin for medicinal uses is easily achieved with the PRP-C18 RP-HPLC resin.

Excellent separation and chemical stability in oligonucleotide isolation is observed. The C18 column provides loading capacities and reliability needed for repeat use.

Identification of the five most common saccharides found in packaged foods, lactose, maltose, sucrose, fructose, and glucose, is easily resolved on the RCX-30 column.

GRPC peptides are found in the entire body. Isolation of seven classic GRPC peptides initiating in the GI tract could implicate disease.

This app note introduces the next generation of SIFT-MS that revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility. Learn about how eliminates the hassles associated with chromatography and outpaces traditional methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.

This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).

Learn about the latest advancement in real-time, direct injection mass spectrometry (MS) that is built to solve the most difficult analytical challenges. Never miss a contamination event again.