Application Notes

Across the world, there has been an explosion of scientific discovery. Fueling this progress is a convergence of breakthroughs in biological sciences, automation, data harnessing, computing power, and software infrastructure. These are already driving changes in laboratory architecture, bringing automation and digitization to the fore to connect the physical and cultural attributes of laboratory space and scientific practice.

We present electrical asymmetrical flow field-flow fractionation with multi-angle light scattering (EAF4-MALS) to derive parameters of a liposomal form of doxorubicin.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

A separation of peptides is performed on a HALO 160 Å PCS C18 column showing excellent peak shape under formic acid conditions.

Discover the GC 2400™ Platform for consistent retention times and repeatable, precise sample injections.

Learn more about how the System Monitoring application provides real-time, contextual details for all Empower™ Software-controlled chromatography systems, helping you easily coordinate your laboratory work and respond dynamically to changing priorities.

A separation of antidepressants is compared between a fully porous C18 and the HALO® PCS C18 column.

Discover the results obtained with the PerkinElmer GC 2400™ Platform for the analysis according to USP grade Carbomer 940.

Discover the results obtained with the PerkinElmer GC 2400™ Platform for the analysis according to USP grade Carbomer 940.

A synthetic peptide panel is screened on the HALO® Peptide PCS C18 and compared to a standard peptide C18 stationary phase.

Built upon Fused-Core® technology, the HALO® PCS C18 maintains peak symmetry at high loading capacities and provides alternate selectivity for C18 bonded phases.

Ambient air analysis and study of the new IONICON Fusion PTR-TOF, providing ultrahigh sensitivities up to 80 000 cps/ppbV, high mass resolving power and ppqV detection limit

The new HALO® PCS C18 phase offers an alternative to chromatographic separations.

In a head-to-head SPP comparison of two positively charged C18 surface chemistries, the HALO 90 Å PCS C18 obtains improved resolution, efficiency, and tailing factors.

Discover the integrated GC 2400™ System and HS 2400™ Headspace Sampler for USP 467.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent analysis according to USP requirements, showing improved productivity and lab time optimization.

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data, and the role of data automation solutions in data analysis and integration.

In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.

Identification of polyphenolic catechin compounds for health and industrial quantification and quality control of tea products.

Nine structurally diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient at 80 °C.

The diterpenoid, paclitaxel, is as a potent chemotherapy agent for breast and ovarian cancer. Here, the isolation of paclitaxel from its major impurities is shown.

Chemically resistant resin bed allows for a wide base of mobile phase choices with excellent anion separation

Identifying benzodiazepine metabolites can be highly valuable in detecting abuse. Metabolites of oxazepam are found containing both hydroxyl and glucuronides.

A reversed-phase HPLC method was developed to separate five steroid hormones, with partition coefficients ranging from 1.47 (cortisone) to 4.5 (pregnenolone).

Complementarity in chromatography ensures accurate purity. Daicel offers non-chiral stationary phases compatible in different modes for cyclic peptide analysis.

The common artificial sweeteners acesulfame K, saccharin and cyclamate Na were analysed using a YMC-Triart C18 UHPLC column in less than 10 min via MS/MS detection.

This tech note describes a method of continuous monitoring of flow rate to provide real-time validation of the LC system performance, improving reliability of results.

GPC/SEC-viscometry enables measurement of true molar masses for carrageenan and detects subtle differences between samples with similar molar mass distributions.