Application Notes: LC

This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.

Despite the utility of the essential oil mixture, it has been shown that allergies can arise from some of the individual components.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

Chromium can pose as a beneficial element or a poison, therefore it is imperative to identify contaminated waters, especially drinking water.

GRPC peptides are found in the entire body. Isolation of seven classic GRPC peptides initiating in the GI tract could implicate disease.

The isolation and identification of 5 common psychedelic compounds was performed using the alkaline ion-pairing agent hexylamine to facilitate excellent resolution.

This note summarizes the optimal methods for the HPLC separation of semaglutide and liraglutide under acidic and alkaline conditions.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

We show the development of HPLC-ELSD methods for high-throughput and sensitive analysis of the lipids in lipid nanoparticles (LNPs), used to administer mRNA vaccines.

Recycling chromatography is a powerful technique that allows the separation of two closely eluting peaks by increasing the column bed length.

KNAUER AZURA UHPLC system, thanks to the low dispersion and operating pressure up to 1240 bar, allows to speed up your method and increase throughput preserving resolution

Trifluoroacetic acid (TFA) as an eluent modifier causes baseline ripples, with negative effect on LOD/LOQ. This can be mitigated by adjusting the pump mixer volume

The KNAUER HPLC Method Converter assists you to modernize the analytical method according to the allowed variations last US and EU Pharmacopeia (USP) chapter 621

A preparative system setup is presented for the purification and fractionation of target substances at flow rates up to 800 ml/min with a max. back pressure of up to 100 bar.

Successful large-scale ion exchange chromatography purification of oligonucleotides provided by BianoGMP GmbH, experts in the productions of therapeutic oligonucleotides

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using columns of shorter length and smaller inner diameter while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using columns of shorter length and smaller inner diameter while maintaining the quality of separation

Discover the outstanding separation of three plasmid DNA isoforms, linear, open circular and supercoiled in HIC mode using YMC’s BioPro HIC BF column.

Real time monitoring of flow using a non-invasive flowmeter offers a new diagnostic tool for measuring performance & troubleshooting problems with pumps serving HPLC systems

This innovative AEX method replaces toxic TMAC with non-toxic choline-Cl, ensuring safety and efficiency in AAV capsid analysis, applicable across multiple AAV serotypes.

This application note shows the performance of the KNAUER AZURA UHPLC system to speed up your method and increase throughput preserving resolution.

The described method of continuous flow rate monitoring provides real-time validation of total HPLC system performance and as such can improve reliability of results.

This article describes how to achieve optimal separation of oligonucleotides and related impurities via a dedicated method development software package.

Accurate purity assessment of oligonucleotide mixtures can be challenging due to their complexity. Daicel offers several solutions that provide unique selectivity.

The measurement of adenosine nucleotides represents important diagnostic measures concerning metabolic standing for the determination of various pathological states.

The coagulation benefits of vitamin K1 are well known, however, the other congeners of the vitamin series are not as common (K2, K3, and K4), but equally contribute to a healthy disposition.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

Discover how the HC-75 series uses a ligand exchange mechanism in order to interact more or less strongly with the analytes of interest.