Application Notes: LC

KNAUER AZURA UHPLC system, thanks to the low dispersion and operating pressure up to 1240 bar, allows to speed up your method and increase throughput preserving resolution

Trifluoroacetic acid (TFA) as an eluent modifier causes baseline ripples, with negative effect on LOD/LOQ. This can be mitigated by adjusting the pump mixer volume

The KNAUER HPLC Method Converter assists you to modernize the analytical method according to the allowed variations last US and EU Pharmacopeia (USP) chapter 621

A preparative system setup is presented for the purification and fractionation of target substances at flow rates up to 800 ml/min with a max. back pressure of up to 100 bar.

Successful large-scale ion exchange chromatography purification of oligonucleotides provided by BianoGMP GmbH, experts in the productions of therapeutic oligonucleotides

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using smaller inner diameter columns while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using columns of shorter length and smaller inner diameter while maintaining the quality of separation

This application notes showcases greener HPLC with less solvent using columns of shorter length and smaller inner diameter while maintaining the quality of separation

Discover the outstanding separation of three plasmid DNA isoforms, linear, open circular and supercoiled in HIC mode using YMC’s BioPro HIC BF column.

Real time monitoring of flow using a non-invasive flowmeter offers a new diagnostic tool for measuring performance & troubleshooting problems with pumps serving HPLC systems

This innovative AEX method replaces toxic TMAC with non-toxic choline-Cl, ensuring safety and efficiency in AAV capsid analysis, applicable across multiple AAV serotypes.

This application note shows the performance of the KNAUER AZURA UHPLC system to speed up your method and increase throughput preserving resolution.

The described method of continuous flow rate monitoring provides real-time validation of total HPLC system performance and as such can improve reliability of results.

This article describes how to achieve optimal separation of oligonucleotides and related impurities via a dedicated method development software package.

Accurate purity assessment of oligonucleotide mixtures can be challenging due to their complexity. Daicel offers several solutions that provide unique selectivity.

The measurement of adenosine nucleotides represents important diagnostic measures concerning metabolic standing for the determination of various pathological states.

The coagulation benefits of vitamin K1 are well known, however, the other congeners of the vitamin series are not as common (K2, K3, and K4), but equally contribute to a healthy disposition.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

Discover how the HC-75 series uses a ligand exchange mechanism in order to interact more or less strongly with the analytes of interest.

Hamilton's PRP-C18 column gave good separation with various gradient profiles and under various particle sizes. The excellent loading capacity of the column make this stationary phase desirable.

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.

This demonstrates how to perform cannabis potency analysis using HPLC-UV, displaying the advantages of this technique for analyzing acidic cannabinoids.

Accurate determination of flow rate is an increasingly favoured method of assessing or validating the performance of a pump serving a liquid chromatography system.

A fast, simple method using the PRP-C18 column allows for simple, efficient identification of the natural and synthetic compounds of vitamin K (K2, K3, and K4).

Contamination of drinking water and food sources is of great concern. Isolation and quantification of the various arsenic states is identified.

Isolation of capsaicin for medicinal uses is easily achieved with the PRP-C18 RP-HPLC resin.

Analyzing crops for beneficial and harmful compounds is an indispensable tool for assessing the viability of various agricultural crops for consumption.

Flavonoids in cannabis, fruits and vegetables protect plants. Hamilton has developed a method to confirm the 7 most common flavonoids in cannabis with the PRP-1 column.

Accurate detection of HAAs is paramount for prevention of overoxidation while still managing enough water sanitation to eliminate water-borne pathogens.