Application Notes: LC

Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column, ensuring symmetric peaks, high sensitivity, and no carryover effects.

The separation of three cell-penetrating peptides (CPPs) was performed using a YMC-Triart C18 UHPLC column, providing sharp peaks for a fast analysis in under 4 min.

Twenty-eight PFAS in human serum were analyzed using a YMC-Triart C18 column. An automated SPE system was coupled to an online SPE column-switching LC–MS/MS method.

Four hydrophilic dipeptides were separated with excellent resolution using a YMC-Triart SIL column. Even structurally similar dipeptides were separated in under 4 min.

The UHPLC analysis of four cyclic peptides is shown. Based on the hydrophobicity of the peptides, a YMC-Triart Bio C4 UHPLC column was chosen for this application.

The analysis of FMOC-derivatized glyphosate and AMPA in water samples was performed using a YMC-Triart C18 UHPLC column at an elevated pH of 9.5.

Efficient and accurate HPLC analysis of lamotrigine in compliance with USP

USP-compliant assay analysis of hydrocortisone using a PerkinElmer LC 300 HPLC System

Efficient and compliant HPLC analysis of pregabalin

Determination of four complex carbohydrates utilizing a PerkinElmer LC 300 HPLC System, a hydrophilic interaction chromatography (HILIC) technique

HPLC method for saccharide content determination via method CRA SACCH.03 through the analysis of nine commercially available high fructose corn syrups

Determination of 16 common cannabinoids utilizing a PerkinElmer LC 300 HPLC System

USP-compliant method for determination of six isoflavone compounds in dietary supplement capsules with the PerkinElmer LC 300 UHPLC System with PDA detector

A rapid and simple LC method for the analysis of six common VOC metabolites in urine for monitoring occupational exposure to VOCs

We show the separation of tacrolimus from its related substances following Ph. Eur. monograph 2244 using the Luna 3 µm C18(2) and Luna Omega µm.

We report the separation of diazoxide and its related organic impurities using a Kinetex ™2.6 µm biphenyl column according to the USP monograph for diazoxide.

Easily determine the allowable adjustments that can be made to European Pharmacopoeia (EP) methods and find the right column for your method.

Quickly view allowable adjustments outlined by the United States Pharmacopeia (USP) and select the proper Phenomenex column for your monograph using this simple guide.

Improve United States Pharmacopeia (USP) method performance with allowable adjustments

A robust and sensitive HPLC method with multi-wavelength UV–vis detector for the analysis of 2-phenoxyethanol and seven parabens in commercially available PCPs .

Critical quality attributes of lentivirus vector products can be assessed by centrifugal field-flow fractionation coupled to multi-angle light scattering (CF3-MALS).

Accurate detection of HAAs is paramount for the prevention of over oxidation, while still managing enough water sanitation to eliminate water-borne pathogens.

Chemically resistant resin bed allows for a wide base of mobile-phase choices with excellent anion separation.        

Contamination of drinking water and food sources is of great concern. Isolation and quantification of the various arsenic states are identified.

Isolation of six common allergens by the utilization of reversed-phase HPLC using an alkaline eluent

Chromium can pose as a beneficial element or a poison, therefore it is imperative to identify contaminated waters, especially drinking water.          

The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.

A variety of C18-type columns are evaluated for the identification of levetiracetam via the USP monograph.

Symmetrical, well-resolved peaks easily meet USP performance requirements for the analysis of levetiracetam impurities.

Symmetrical, well-resolved peaks easily meet USP performance requirements for the analysis of pramipexole dihydrochloride.