Merck

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.

Webinar Date/Time: Thu, Mar 2, 2023 11:00 AM EST

This application note demonstrates the extraction of 25 PFAS analytes from drinking water using Supelclean™ ENVI-WAX™ SPE as described in regulated method EPA 533.

When detecting and analyzing PFAS, the greatest hurdles lie in the various matrices in which PFAS are found. Custom methods and extensive expertise help to solve these issues.

The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.

On Demand Webcast Understand the challenges for matrix-rich sample analysis using HPLC and/or UHPLC and how to overcome them. Learn how to leverage lab efficiency by simplifying the HPLC workflow using monolithic silica columns.

Experts will be sharing their experience in providing tips for protein biologics sample preparation. Special focus is on reduction and deglycosylation for characterizing antibody-drug conjugates, as well as enzyme and chemical treatment options to ensure desired results when deglycosylating glycoprotein samples.

Three Merck experts sharing their personal experiences in a cordial roundtable discussion counting down 5 tips to incorporate into your pharma analysis & QC validation strategy.

For effective analytical practices, it is important to understand and control the binding of analytes to filters and pre-filters. This summary discusses the effect of sample filtration on analyte binding.