Application Notes: LC

The molecular similarity between Humira® and Yervoy® biosimilars and the corresponding innovator reference products is examined using analytical SEC, RPC and HIC.

This white paper discusses the advantages of using fast, efficient HALO® Fused-Core® Technology columns and manipulating selectivity to quickly develop methods, for fast high efficiency LC and LCMS separations.

Simple sugars ribose and xylose (are easily and quickly separated on a very stable amide column using high acetonitrile concentration in the mobile phase.

PharmaFluidics introduces a new µPAC™ capLC column that offers unprecedented performance and that given its low back pressure can be used up to flow rates of 15 µL/min.

Solid-phase extraction (SPE) is a powerful technique for LC­–MS analysis. SPE offers benefits for various solutes from a wide range of samples. Modern SPE systems can remove unwanted compounds and streamline methods.

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications.

-How to translate methods, maximize resolution, and comply with USP -Optimizing HPLC/UHPLC method development workflows -Column coupling can provide improved sample detail and high peak capacities

- UHPLC-MS method for antibody analysis - Large-size protein separation at high temp

Multidimensional LC/MS is a powerful tool to gain info in the laboratory. Analyzing ADCs with multidimensional LC/MS provides fast data for CQAs.

A sensitive, robust method for analysis of glyphosate in wide range of foods using a simplified sample preparation procedure effective for challenging matrices

Fast and sensitive HPLC method with post-column derivatization for analyzing Fumonisins in grains and feeds at levels as low as 0.01 ug/g

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

A solution for amino acids analysis, these methods were optimized to comply with system suitability requirements of Pharmacopoeia 8.0 methods.

Highly sensitive analysis of aflatoxins and ochratoxin A to guarantee the safety of hemp crop and hemp-containing consumer products.

An easy and sensitive method to analyze Aflatoxins B1, B2, G1, G2 and Ochratoxin A in cannabis plant and edible products at levels below established by state regulations.

A sensitive HPLC method allows analyzing cannabinoids, including THC and CBD, in hemp and hemp-containing products to ensure compliance with the 2018 Farm Bill.

This application note demonstrates the development of an SFC separation method for 46 highly polar compounds on different columns using an increased amount of modifier.

This technical overview presents the measurement of the instrument detection limit (IDL) at two different conditions of MRM dwell times.

The applicability of AF4-UV-MALS for sizing and quantification of adeno-associated virus (AAV) samples with different degrees of aggregation is presented.

This study investigates the capabilities of asymmetrical flow field-flow fractionation coupled with MALS for the detection of carbon nanotubes in soot and soil.

The applicability of AF4-UV-MALS for sizing and quantification of adeno-associated virus (AAV) samples with different degrees of aggregation is presented.

This study investigates the capabilities of asymmetrical flow field-flow fractionation coupled with MALS for the detection of carbon nanotubes in soot and soil.

This study demonstrates the combination of inverse supercritical fluid extraction and miniaturized AF4-MALS for the analysis of nanoparticles in commercial sunscreens.

This study demonstrates the combination of inverse supercritical fluid extraction and miniaturized AF4-MALS for the analysis of nanoparticles in commercial sunscreens.

This study describes the analysis of PLGA particles under physiological conditions using centrifugal field-flow fractionation coupled with dynamic light scattering.

This study describes the analysis of PLGA particles under physiological conditions using centrifugal field-flow fractionation coupled with dynamic light scattering.

This study describes the separation of nanoplastics and determination of their surface charge by electrical asymmetrical flow field-flow fractionation.

This study describes the separation of nanoplastics and determination of their surface charge by electrical asymmetrical flow field-flow fractionation.

Electrical asymmetrical flow field-flow fractionation coupled with MALS was used to characterize the NIST monoclonal antibody reference material 8671.