Application Notes: LC
High Recovery of Peptides Using Strata-X PRO Solid-Phase Extraction
For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.
A Practical Guide for Small and Large Biomolecule Sample Preparation
In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.
Barbiturates from Serum Using Strata-X PRO Solid-Phase Extraction
Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.
Separation of Selected Components of Ylang-Ylang Oil
Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications
Nanomedicine, well-characterized – how FFF-MALS provides detailed and quantitative analysis of size, structure, concentration and encapsulation
• FFF–MALS offers deep and unbiased particle characterization. • Regulatory bodies view FFF–MALS as essential for various nanomedicines.
Analytical Method Development for Reversed-Phase HPLC
• Parameter variety adds complexity to analytical method development. • Reversed-phase HPLC offers an efficient approach to simply this process.
Transferring Analytical Methods: Smoothing the Transition
• Transferring from HPLC to UHPLC comes with both benefits and costs. • Making the transition more predictable can boost efficiency. • Informed equipment and procedural decisions can combat transfer challenges.
Challenging analysis of Amyloid β proteins
Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented.
Transfer of an EP Method for Mebendazole
This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.
Simultaneous Determination of Water- and Fat-Soluble Vitamins in Tablets and Energy Drinks
This application note describes workflow for the simultaneous quantitative analysis of fat-soluble and water-soluble vitamins in drinks and food supplement tablets.
Identity Confirmation and Accurate Quantitation of a Genotoxic Impurity
Simultaneous Liquid Chromatographic Analysis of Acetaminophen Impurities
This application note demonstrates the capabilities for Dual LC to run independent HPLC and UHPLC methods simultaneously using one instrument.
Protein Aggregate Analysis of Monoclonal Antibodies
The Thermo Scientific Vanquish Duo system for Dual employs two separate flow paths for simultaneous analysis of complex samples.
Simultaneous Analysis of Monoclonal Antibodies
The Thermo Scientific Vanquish Duo system for Dual LC can run two methods simultaneously on one instrument, regardless if identical chromatographic conditions are used.
Doubling Chromatographic Throughput Using Dual LC
The Thermo Scientific Vanquish Duo system for Dual LC enables two sample runs concurrently, so samples to run in half the time, improving pharmaceutical drug analysis.
Automated Method Development in HPLC for the Quantitative Determination of Catechins in Tea
This note discusses the use of a software-based workflow for automated method development in HPLC as a straightforward approach with a significant reduction in process time.
Tandem UHPLC Operation for High-Throughput LC–MS Peptide Mapping Analyses
This note addresses productivity and throughput improvement of existing LC–MS methods.
Tandem NanoLC-MS: Maximum MS Utilization for Deep-Dive Proteomic Analysis
This note addresses the optimum solution for the true productivity in all nanoLC-MS proteomics workflows.
Tackle Method 625.1 with Superior Evaporation
See the advantage in optimizing your solvent evaporation for maximum accuracy and precision to comply with U.S. EPA Method 625.1