Application Notes: LC

In this white paper, we look at an intelligent solution for hydrophilic interaction liquid chromatography method development using complementary HILIC phases

See how the combination of ACE stationary phases with an offline version of Chromsword2 method development software can drastically aid method development

In this knowledge note we look at how the ACE method translation tool can be of use when translating methods from HPLC to UHPLC and vice versa

• 4D LC offers significant benefits for biotherapeutic characterization. • Multidimensional LC can help find previously undetected impurities. • User-friendly software offers a solution to 4D-LC challenges.

A sensitive HPLC method allows analyzing cannabinoids, including THC and CBD, in hemp and hemp-containing products to ensure compliance with the 2018 Farm Bill

Highly sensitive analysis of aflatoxins and ochratoxin A to guarantee the safety of hemp crop and hemp-containing consumer products.

Highly sensitive analysis of aflatoxins and ochratoxin A to guarantee the safety of hemp crop and hemp-containing consumer products.

A sensitive HPLC method allows analyzing cannabinoids, including THC and CBD, in hemp and hemp-containing products to ensure compliance with the 2018 Farm Bill.

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.

Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.

Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.

This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.

When working with milk as a matrix, Strata-X PRO SPE removes phospholipids more efficiently than traditional SPE to reduce any ion suppression that may occur during LC-MS/MS analysis.

Strata-X PRO consists of a new type of polymeric SPE sorbent combined with matrix removal technology to revolutionize sample extractions and matrix clean-up by eliminates the conditioning and equilibration steps.

When working with milk as a matrix, Strata-X PRO SPE removes phospholipids more efficiently than traditional SPE to reduce any ion suppression that may occur during LC-MS/MS analysis.

This application displays that for a range of pain relievers, an easy 3-Step SPE method can be implemented and produce high recoveries.

Strata-X PRO was chosen to extract a panel of acids, neutrals, and bases from plasma. This simple method eliminates time-consuming method development and recovery for extremely polar analytes.

In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.

For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.

In this webinar, learn how to achieve cleaner, more concentrated, and targeted sample preparation methods to help with downstream analysis for both analytical and biopharmaceutical labs.

For this peptide application, two different types of polymeric SPE (WCX and SAX) were tested in parallel with Strata-X PRO SPE and compared in regards to recovery and % variation.

Using Strata-X PRO to extract barbiturates from serum saves time by reducing the method to 3 quick and easy steps. In addition, the matrix is more effectively clean-up vs protein precipitation.

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications

• FFF–MALS offers deep and unbiased particle characterization. • Regulatory bodies view FFF–MALS as essential for various nanomedicines.

• Parameter variety adds complexity to analytical method development. • Reversed-phase HPLC offers an efficient approach to simply this process.

• Transferring from HPLC to UHPLC comes with both benefits and costs. • Making the transition more predictable can boost efficiency. • Informed equipment and procedural decisions can combat transfer challenges.

Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented.

This application note demonstrates how sensitive UV detection provides quantitation of a genotoxic impurity at low ng/mL level.