Application Notes: LC

In this application note high-resolution SCX was coupled directly to an ultrasensitive online native MS using YMC’s BioPro IEX SF to analyse mAb charge variants.

The use of a C18 column for the analysis of indoxyl sulfate as part of a research study to measure the total levels in a simulated blood serum environment is illustrated.

Discover Coiled microextraction and SPME field collection and injection devices using portable GC–MS for separation, detection, and identification of explosive materials.

Vitamin C is essential for the repair of tissue and is thought to lower cancer risk. This application brief describes use of a Quasar biphenyl column in this analysis.

Plavix tablets contain the active ingredient clopidogrel hydrogen sulphate, readily analyzed by HPLC. Use of a Quasar C8 column in the analysis of Plavix is described.

Detect whisky and spirits adulteration. Field-portable GC–MS provides rapid determination of denatured alcohol when added to spirit drinks to raise alcohol content.

PharmaFluidics’ superior fabrication robustness of microfabricated LC columns results in sub-second retention time variation over three different μPAC™ capLC columns.

A CDS implemented appropriately and managed correctly can simplify system administration, ensure regulatory compliance and adherence to data integrity guidelines

Software solutions can guide all stages of pharmaceutical stress testing, from prediction of degradation chemistry to analytical development and, project management.

Synthetically derived food and beverage dye analysis to meet regulatory requirements aimed at reducing the risk of allergies, cancers, and attention deficits.

This application note demonstrates the ease of implementation and processing of a full method validation with a CDS using eWorkflow procedures based on ICH Guidelines.

First 220 nm laser in solid-state detectors overcomes DAD barriers for preparative chromatography with low limits of detection, no maintenance, affordability, and more.   

Analyzing crops for beneficial and harmful compounds is an indispensable tool for assessing the viability of various agricultural crops for consumption.

Teach a virtual chromatography lab with LC simulation software. See how one chemistry professor replaced hands-on labs with online experiential learning.

This white paper demonstrates the advantages of Fused-Core® technology in both comprehensive protein glycan characterization as well as a rapid and routine LC method for process control.

From siRNA to mRNA to DNA, separating full length product from impurities can be challenging. Taking into consideration the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use to characterize or purify your molecule.

Released & 2AB labelled N-glycans of similar structure, are shown to be well separated using HILIC methodology with the Avantor® ACE® Glycan column. 

In this publication, the concentrations of various amino acids in a culture fluid under different culture conditions were monitored using the Hitachi LA-8080 amino acid analyser.

To analyse fatty acids, they are derivatised to FAME’s for analysis by GC.  Here we separate 22 FAMEs with two CLA isomers using the Avantor® Hichrom HI-10 phase.

In this white paper we discuss the importance of correct mobile phase buffer selection and pH control in LC and LC–MS method development.

Our compilation of Avantor® ACE® applications for key analyte classes in cannabis products and potential contaminants provides technical support for this key expanding area.

One of the key parts of a robust HPLC method is one of the simplest HPLC vials. This guide breaks down this often difficult area and helps you find the compatible solutions for your instrument.

Here, we describe the utility of a new rugged HALO® SPP design for environmental PAH analysis using a highly selective phase offering excellent peak shape, resolution.

This application note demonstrates a high-resolution LC–UV method for the separation of 18 PAH compounds using the new HALO® PAH column with Fused-Core® technology.