Application Notes: LC

This application note demonstrates the direct analysis of biogenic amines in Tempranillo red wine using ion pair chromatography prior to MS analysis.

This white paper demonstrates a vendor’s perspective on recent trends in regulations and the potential future direction for the industry.

The baseline separation of various chlorophenols, that only differ in the amount and/or position of the chlorine substituents, is made possible using YMC-Triart C18 ExRS.

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.  

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.

Retention under reverse-phase conditions as a consequence of polar end capping on stationary phase provides sites for interaction with the polar entities within Warfarin.

This application illustrates the efficient separation of three sulfa drugs using a Quasar C18 HPLC column.

The Quasar C18 HPLC phase offers high efficiency separation of the semi-synthetic antibiotic, amoxicillin.

We present retention-time models for peptides and proteins that link their elution times to solvent fraction and temperature.

Learn how impurity-monitoring software can improve your understanding of your process route and help you track fate and purge.  

Adsorption of metal-sensitive analytes in LC-based assays can negatively impact data. Learn how to minimize analyte–surface interaction and improve reproducibility.

We discuss the theory, principles, and key equations required for method translation for both isocratic and gradient LC methods using the Avantor® ACE® Method Translator tool.

Elution profiles based on mAb glycan structures produced by the TSKgel® FcR-IIIA-NPR™ affinity chromatography column correlate with results from HILIC glycan profiling.  

Highlighting the use of the dial-a-mix method for screening different mobile-phase pH conditions during method development of IEX charge variant analysis.

This application note details the development of a HPLC method for analyzing CBD and Melatonin in an over-the-counter sleep aid.

This application note highlights the ability of YMC-Triart C18 to separate 11 common cannabinoids encountered during potency testing.

A loading study for purifying cannabidiol (CBD) from a commercially available “high-CBD” hemp oil extract

Demonstrating the use of YMC’s new 2µm Diol stationary phase for scaling down size exclusion analyses

Here we present an innovative approach for the characterization of nanoplastic particles using centrifugal field-flow fractionation coupled with UV, multi angle light Scattering detection, and raman microscopy.

The Torion® T-9 GC/MS system has characterized several high boiling point organochlorine pesticides in tea samples in less than 10 minutes.

This application note discusses using a Quasar™ C18 column to analyze azithromycin, an antibiotic used to treat various bacterial infections.

SPME-UHPLC/MS/MS offers an efficient alternative for the analysis of veterinary drug residues in animal tissue as compared to traditional sampling procedures.

The Quasar biphenyl HPLC phase offers high efficiency separation and excellent peak shape of the synthetic antibiotic, ciprofloxacin.

This application note describes using a Quasar biphenyl LC column in analyzing several cephalosporins, a mixture of first and second generation β-lactam antibiotics.

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) for better characterization of the Fc fragment.

Selectivity of two high-pH stable Agilent InfinityLab Poroshell 120 C18 columns is compared with pesticides using a pH 10 formate buffer and acetonitrile gradient.

This application combines cysteine proteases IgdE and IdeS, to observe conserved and hypervariable regions of the antibody, as well as identification of other variants.