Application Notes: LC

The Epic C18 column provides efficient and repeatable separations for finasteride, meeting all suitability requirements in the USP monograph.

The superior base deactivation and high-density bonding technology of the Epic C18 phase yields excellent peak shape in betamethasone analyses.

This application brief describes the use of an Epic C18 column for the analysis of acetaminophen, aspirin, and caffeine yielding rapid and reproducible results.

This application brief describes the use of an EpicTM C18 to analyze three ginsenosides using a method based on the Chinese Pharmacopeia.

Learn how to use flash chromatography and prep HPLC for protein purification, parameters that improve resolution, and how to select the stationary phase and solvent.

This note demonstrates the determination of PAH4 inedible oils with automated sample enrichment and matrix elimination (online solid-phase extraction - online SPE).

This application demonstrates the efficiency, throughput, and reliability of a dual-injection system for finished pharmaceutical products and in-process APIs.

Cannabinoids have similar molecular structures, making purification a challenging step. Learn how centrifugal partition chromatography can simplify this process.

Synthetically derived food and beverage dye analysis to meet regulatory requirements aimed at reducing the risk of allergies, cancers, and attention deficits.

Sulfide compounds found in garlic oils are used in therapeutics and prophylaxis of certain cancers and are prevalent in cell health.

Identification and quantification of the raffinose family of oligosaccharides allows a more thorough understanding of an individual’s gut health.

AEX using a TSKgel® DNA-NPR column offers a rapid method for discriminating between covalently closed circular, open circular, and linear forms of plasmid DNA.

Identification of the five most common saccharides found in packaged foods, lactose, maltose, sucrose, fructose, and glucose, is easily resolved on the RCX-30 column.

Robust and accurate primary sequence confirmation and monitoring of post-translational modifications of the SARS-CoV-2 spike protein using the BioAccord LC–MS system.

Eliminate the need for column conditioning, improve recovery, and improve repeatability by minimizing non-specific oligonucleotide interactions with metal surfaces.

A rapid, sensitive, and reproducible method for understanding the SARS-CoV-2 spike protein N-glycosylation profile using the GlycoWorks RapiFluor MS N-Glycan Kit.

Review of the best practices for oligonucleotide analysis and purification to achieve high quality oligonucleotides for COVID-19 diagnostic or therapeutic applications.

A HILIC method for baseline separation of ribavirin from isobaric and structurally similar species within 6 minutes using an ACQUITY UPLC BEH Amide column.

This work demonstrates how to achieve sharper peaks and faster elution of basic analytes like umifenovir using a mixed-mode Atlantis PREMIER BEH C18 AX column.

We discuss the role of LC and LC–MS for select COVID-19 applications to better understand the use of analytical technologies mobilized in the fight against the pandemic.

This white paper demonstrates a vendor’s perspective on recent trends in regulations and the potential future direction for the industry.

This application note demonstrates the direct analysis of biogenic amines in Tempranillo red wine using ion pair chromatography prior to MS analysis.