Application Notes: LC

This app note introduces the use of the Nexera XS inert UHPLC, which utilizes a metal-free flow path for accurate and reproducible analysis of nucleotides.  

This app note introduces an analytical method for the separation of oligonucleotides of different length by ion-exchange chromatography using the Nexera XS Inert. 

This study demonstrates how to increase sample throughput for glycan characterization workflows using the Agilent AssayMAP Bravo liquid handling platform.

Peptide-mapping analysis shows excellent performance and high method compatibility compared to the Agilent 1290 Infinity II LC System.

This paper describes the requirements for electronic records and electronic signatures for regulated pharmaceutical organizations.

The 1290 Infinity II Bio LC including High-Speed Pump, with its iron‑free flow path, is optimally suited for the conditions used in biochromatography.

The Agilent Bio-Monolith rProtein A (recombinant protein A) analytical column is the latest addition to the Bio-Monolith and affinity chromatography family.

Analysis of antibody drug conjugates using hydrophobic interaction chromatography with the Agilent 1290 Infinity II Bio LC System

Superior resolution in size exclusion chromatography (SEC) protein separation made possible by the Agilent 1290 Infinity II Bio LC System.

The Agilent 1290 Infinity II Bio LC System is the new platform for UV and MS-based primary structure and PTMs analysis of mAbs.

Accurate detection of halo acetic acids is paramount for the prevention of over oxidation, while still managing enough water sanitation to eliminate water-borne pathogens.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

This application introduces the automated analysis of fluorescent diastereomers of the proteinogenic D/L-amino acids using derivatizing reagents with chiral structures.

This goal of this note is identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC–MS in a top-down experiment.

The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.

In this study, we confirm the high selectivity of CPC and its capability to purify a set of key compounds and enrich several minor cannabinoids in a single step.

Exploring isotopes in petrochemical materials can reveal information on original source materials, and maturation and biodegradation processes on different time scales.

Detect aflatoxins B1, B2, G1, and G2 and sterigmatocystin in complex (and simple) sample matrices using a streamlined approach with LC.

Antiretrovirals have come back to the forefront of separation science at this moment in time, as they have found use in the fight against SARS-CoV-2.

The ALEXYS Carbohydrate Analyzer is a dedicated instrument for the routine analysis of sugars and oligosaccharides in F&B products based on HPAEC-PAD.

Erythromycin analysis in creams, lotions, etc., based on HPAEC-PAD using the ALEXYS Antibiotics Analyzer according to the official 2018 USP 41—NF36 monograph.

SMX and TMP are the active ingredients of Co-trimoxazole or Bactrim. They can be analyzed easily and inexpensively using HPLC with pulsed amperometric detection.

The ALEXYS HPAEC-PAD Analyzer is used for the analysis of both antibiotics, in accordance with the USP 38 monographs.

A HPAEC-PAD method is presented for the sensitive analysis of mono-, di-, and trisaccharides in plant tissue extracts and root exudates..

This application note demonstrates a fast, selective, and sensitive method for the analysis of lactose and isomers based on HPAEC with Pulsed Amperometric Detection.

A HPAEC-PAD method with a four-step potential waveform is applied for the analysis of Erythritol, Xylitol, Sorbitol, Mannitol, and Maltitol, resulting in excellent reproducibility.

The ALEXYS Antibiotics Analyzer is used for routine assay and impurity analysis of Azithromycin in various formulations according USP 41 monographs.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions. 

This article introduces a comprehensive fractionation for both UV absorbing and non-UV absorbing compounds using a newly designed PDA-ELSD triggered preparative LC.  

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.