Application Notes: LC-MS

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data, and the role of data automation solutions in data analysis and integration.

The common artificial sweeteners acesulfame K, saccharin and cyclamate Na were analysed using a YMC-Triart C18 UHPLC column in less than 10 min via MS/MS detection.

A validated method was developed for screening short to long chain PFAS in industrial water, using direct injection with no sample preparation.

A multimodal method using HILIC and anion ion exchange chromatography for high peak resolution was developed to separate ultra-short to medium chain PFAS.

Utilizing the Shodex HILIC VT-50 2D, a method was developed on LC–MS to analyze ultra-short chain (C1¬–C4) PFAS though long chain (C8–C10) PFAS.

A validated method was developed for screening short to long chain PFAS in ground water, using direct injection with no sample preparation.

This application note outlines a QuEChERS method for the simultaneous analysis of cannabis for 67 pesticides and 5 mycotoxins residues in cannabis flower.

This application note explains how the Mnova automation solution enables you to streamline the reaction optimization process.

This article explores how to use this powerful, free, simulation tool to simplify and speed up LC–MS/MS method development.

Xylazine has emerged as a prevalent adulterant in illicit drugs. A robust SPE and LC-MS/MS method for analyzing xylazine, fentanyl, and other adulterants is presented.

SweetSep is a new line of HPAEC columns from Antec Scientific for superior separation of all classes of carbohydrates including N-glycans using PAD or MS detection.

This application note describes how Dow AgroSciences created efficiency in method development by incorporating method development software into their best practices.

Improved and universal subunits LC–MS analysis of multiple classes of monoclonal antibodies using in-line electrochemical reduction  

Here we introduce LC/MS analysis methods using the Shodex™ HILICpak™ VC-50 2D column for various cationic neurotransmitters.

The HILICpak™ VG-50 series columns are able to achieve high recovery rates of saccharides, organic acids, and amino acids.

Mucopolysaccharidosis and oligosaccharidosis are LSDs caused by enzyme deficiencies. Early diagnosis is key using chromatographic separation and MS/MS identification.

Demonstration of the sensitivity gain for the Pierce peptide mix, which is achieved when using UHPLC columns of different i.d.s, as well as a micro-LC approach.

Reversed-phase LC–MS analysis of two phospholipids—LPC (16:0) and PC (34:2)—using a bioinert coated column in comparison with a regular stainless steel one.

This application note presents a side-by-side comparison of the AdvanceBio and GlycoWorks kits for the preparation and analysis of released N-glycans.

This app note demonstrates the excellent performance of mediterranea sea18 for MMA, MCA, and HCyr quantification by LC–MS for second tier tests in newborn screening.

This application analyzes saccharides, organic acids, and amino acids using a Shodex™ HILICpak™ VG-50 2D column, with LC–MS alkaline gradient conditions.

The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.

Go ahead, take the stress out of your LC method transfer journey with our free master guide. Features a compilation of proven techniques to help you succeed.

Learn how to transfer your LC methods the right way. A short case study with helpful guidance on how to transfer compendial methods, without needing revalidation.  

This article demonstrates how you can accelerate peptide mapping analyses with Tandem LC-MS workflows by reducing downtime from column reconditioning in gradient runs.

This application note provides a reliable HPLC method for profiling PS80 samples to help you maintain drug consistency and quality across every production batch.

This fast, simple LC-MS/MS workflow for the direct analysis of polar pesticides in spinach provides good retention and peak shape over hundreds of matrix injections.

Application guide to advanced sample preparation for chromatography analysis and mass spectrometry techniques for PFAS's more difficult matrices.

Laboratory productivity increase is demonstrated using an SDVB polymer SPE and C18 column selectivity.