Waters Podcast:Improving Water Analysis with Automated Sample Prep and UPLC
Everything you've ever wanted to know about UPLC: A practical guide to scientific and business achievement
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In this podcast series, we’ll be discussing how users can benefit from UPLC separations technology in their laboratories. We have heard all the hype about specifications from marketing, but what is it about this technology that, when in the hands of real users, allows them to achieve the scientific and business benefits that the chromatography community has proclaimed so widely in peer-reviewed journals, scientific meetings, and testimonials in the media?
Through a variety of topics and scientific examples, this series will help you to gain a better understanding of UPLC technology, how to realize the benefits for your applications, and how to easily adopt UPLC technology for instant chromatographic success.
Labs performing drinking water analysis today spend great amounts of time concentrating liter volumes of sample down to manageable levels before injecting onto an LC system. This takes time and with multiple steps can lead to variability in the process. This system enables labs to get to parts per trillion levels with just 20-mL samples, while automating the concentration and SPE process enabling consistent results without user intervention.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
