Optimizing Separations Using Coupled Columns and Window Diagramming
In this month's "GC Connections," guest columnist Dean Rood writes about optimizing separations using combinations of two columns connected in a series. These coupled column systems produce peak separations that are a combination of separations achieved on each column individually. He describes the geographical window diagramming approach to determining the optimal combination of column lengths for several separations and column combinations and compares the results with those obtained using mixed stationary-phase chemistry.
LCGC 17(10), 914–922 (1999)
Next Generation Peak Fitting for Separations
December 11th 2024Separation scientists frequently encounter critical pairs that are difficult to separate in a complex mixture. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting.
Identifying and Rectifying the Misuse of Retention Indices in GC
December 10th 2024LCGC International spoke to Phil Marriott and Humberto Bizzo about a recent paper they published identifying the incorrect use of retention indices in gas chromatography and how this problem can be rectified in practice.
