HPLC Detection and Evaluation of Chiral Compounds with a Laser-Based Chiroptical Detector
The sensitivity and ruggedness of chiroptical detectors have improved considerably during the past decade. In this article, the authors examine more than 230 chiral compounds using the latest laser-based polarimetry detector for high performance liquid chromatography (HPLC). They also examine the relationship between optical rotation at the detector wavelength of 675 nm and the sodium D line. In addition, the authors consider the sensitivity, linear dynamic range, and effect of solvent composition on rotation and its general use as an HPLC detector for chiral compounds.
LCGC 17(10), 946–957 (1999)
Polysorbate Quantification and Degradation Analysis via LC and Charged Aerosol Detection
April 9th 2025Scientists from ThermoFisher Scientific published a review article in the Journal of Chromatography A that provided an overview of HPLC analysis using charged aerosol detection can help with polysorbate quantification.
Removing Double-Stranded RNA Impurities Using Chromatography
April 8th 2025Researchers from Agency for Science, Technology and Research in Singapore recently published a review article exploring how chromatography can be used to remove double-stranded RNA impurities during mRNA therapeutics production.
