"Lean" Approaches to Reduce Waste when Performing Chromatography Analysis
"Lean" approaches are used to reduce wastes and costs when performing chromatographic procedures. The terminology of this approach is introduced in this article, together with illustrative examples and suggestions.
"Lean" approaches are used to reduce wastes and costs when performing chromatographic procedures. The terminology of this approach is introduced in this article, together with illustrative examples and suggestions. Although this “Lean” methodology was originally developed for industrial use or factory environments, it is increasingly being used in analytical laboratories — most notably in pharmaceutical companies. A follow-up article in the next issue of The Column will describe how to achieve reductions in variations (“Sigma”) that can occur in chromatographic operations.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
