Scientists from Roche, in collaboration with the University of Lausanne, Switzerland, have developed a spectral database to help organizations in the fight against counterfeit medicines.
Scientists from Roche, in collaboration with the University of Lausanne, Switzerland, have developed a spectral database to help organizations in the fight against counterfeit medicines. The database is part of a study published in Forensic Science International.1
The database was compiled by using near-infrared and raman spectroscopy to analyse the counterfeits of a range of pharmaceutical products. Unsupervised chemometric techniques were used to identify the classes within the datasets and gas chromatography–mass spectrometry and fourier transform infrared spectroscopy were used to determine the number of different chemical profiles within the counterfeits.
Taking these chemical profiles, the study claims “the model is able to compare the spectrum of a new counterfeit with that of previously analysed products and to determine if a new specimen belongs to one of the existing classes.”
The study is available online ahead of print.
1. F. Beena et al., Forensic Science International, online 26 May 2011.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.