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There is a resurgence of interest in chemical derivatization schemes in separation science, particularly in sample preparation. Here’s why.

Paying attention to the details of mobile-phase preparation can have a big impact on the reproducibility of HILIC separations.

A look at techniques for charge-variant analysis of monoclonal antibodies and the question of whether pH gradients are really better than salt gradients

The fundamental principles of ion-exchange solid-phase extraction

Three main points summarize the best ways to be successful in GC:capillary GC is clean GC; practice, practice, practice; and be a student of GC.

Click the title above to open the LCGC Europe January 2018 regular issue, Vol 31, No 1, in an interactive PDF format.

Click the title above to open the LCGC North America January 2018 regular issue, Vol 36 No 1, in an interactive PDF format.

The LCGC Europe/HTC-15 Innovation Award was launched to celebrate the work of scientists who are innovatively evolving the field of hyphenated techniques.

The newly appointed Chromatographic Society Lecturer, Mel Euerby, visited the University of Sunderland in early November in the first official outing of the role.

Researchers from University College London have developed a novel method of characterizing the mechanical strength of agarose-based chromatography resins used in the manufacturing of biopharmaceuticals.

Avantor Inc. has completed the acquisition of VWR Corporation for an approximate amount of $6.5 billion.

Click the title above to open The Column December 12, 2017 Europe & Asia issue, Volume 13, Number 18, in an interactive PDF format.

Click the title above to open The Column December 12, 2017 North American issue, Volume 13, Number 18, in an interactive PDF format.

It’s very easy to be comfortable with what you have. It’s only when we realize what could be, that we become interested in changing things.

Selected highlights of innovative chromatography products.

Peak Scientific has created a new online calculation tool to help laboratories that use gas chromatography (GC) to quickly identify the ideal gas solution for their specific GC instrument.

The American Chemical Society has awarded Kevin Schug with the J. Calvin Giddings Award for Excellence in Education in recognition of his efforts to improve the educational experience of students in the field of analytical chemistry.

Dwight Stoll has been awarded the EAS Young Investigator Award at the recent Eastern Analytical Symposium held in Plainsboro, New Jersey on 15th November.

Sciex Diagnostics, the in vitro diagnostics (IVD) division of Sciex, has announced a joint venture with Zhejiang Dian Diagnostics (Dian).

A preview of HTC-15, which will be held at Cardiff City Hall, Cardiff, United Kingdom, from 24–26 January 2018.

Click the title above to open The Column December 05, 2017 Europe & Asia issue, Volume 13, Number 17, in an interactive PDF format.

Click the title above to open The Column December 05, 2017 North American issue, Volume 13, Number 17, in an interactive PDF format.

When I want to hear some humorous stories, there are few friends in the instrument manufacturing and sales business I can contact. If I ask them about their recent experiences with the cannabis industry, their stories will cover topics ranging from instruments purchased using duffel bags of cash (cue images of large men in suits and sunglasses packing heat) to recent college graduates who cleared $25 million in their first year of business selling cannabis butter (cue images of large men at breakfast laughing uncontrollably).

Click the title above to open the LCGC North America December 2017 Corporate Capabilities, Vol 35 No s12, in an interactive PDF format.

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Traditional extraction methods for food samples, such as liquid–liquid extraction and Soxhlet extraction, are often time-consuming and require large amounts of organic solvents. Therefore, one of the objectives of analytical food safety studies currently has been the development of new extraction techniques that can improve the accuracy and precision of analytical results and simplify the analytical procedure.

Gaussian peak shapes in chromatography are indicative of a well-behaved system. Such peak shapes are highly desirable from the perspective of column packing technology. From an analyst’s point of view, Gaussian peaks provide improved sensitivity (lower detection limits) and allow ease of quantitation. In practice, one can obtain peaks that tail, front, or concurrently front and tail for reasons such as column packing issues, chemical and kinetic effects, and suboptimal high performance liquid chromatography (HPLC) system plumbing and detector settings. Here, we discuss a number of approaches for peak shape measurement that are available in modern chromatography software, along with their advantages and drawbacks. A new “total peak shape analysis” approach is suggested that facilitates detection and quantification of concurrent fronting and tailing in peaks. Several remediation approaches are proposed that can help chromatographers analyze and improve peak shapes.

The authors discuss metrics for monitoring data integrity within a chromatography laboratory, from the regulatory requirements to practical implementation.