GC Troubleshooting — A Troubleshooter's Tool Kit
John Hinshaw examines the tools and accessories that gas chromatographers use in their laboratories.
Flow Rate and Peak Spacing
Flow-rate changes might or might not be acceptable means to adjust retention.
Critical Pairs in Column Chromatography: A Primer for Pharmaceutical Method Validation
This article reviews several common applications of the critical-pair approach to column chromatography as it is applied under pharmaceutical guidelines and validation strategies.
Handling Fast Peaks
John Hinshaw examines the effects of system time constants and sampling rates on apparent peak shapes and areas.
New Chromatography Columns and Accessories at the 2003 Pittsburgh Conference, Part I
The first of two columns about new chromatography columns, accessories, and sample preparation products introduced at Pittcon 2003.
LC Columns — The Top-10 List
John Dolan provides 10 tips for the proper care and use of LC columns.
Validation of Bioanalytical Methods — Highlights of FDA's Guidance
This column explores and highlights recently published guidelines for bioanalytical method validation.
The Thermally Tuned Tandem Column Approach to Optimizing Selectivity in HPLC
The authors compare thermally tuned tandem column separations with single-column optimization strategies.
Preparing the Laboratory for a Gas Chromatograph
John Hinshaw examines basic laboratory heating, ventilation, cooling, electrical, and space requirements for the successful installation of a gas chromatograph.
Pittcon Product Showcase
Products and literature for separation science.
Success with Evaporative Light-Scattering Detection
Craig Young and John Dolan provide tips and techniques for evaporative light-scattering detection.
Mobile-Phase Cleanup Using Solid-Phase Extraction Disks
The authors describe a fast, simple procedure for purifying mobile phase that uses SPE disks during the filtration step.
Two Early, Influential Symposia in the Development of Gas Chromatography
"Milestones in Chromatography" discusses the beginnings of gas chromatography in the UK and the first two international symposia that played an important role in the dissemination of the technique.
November Events
Events for November 2003...
A GC–MS Purge-and-Trap Method Comparison Study for MTBE Analysis in Groundwater
This article describes a study that assesses the ability of commercially available GC–MS methods to meet project criteria for MTBE in groundwater matrices.
More Peak Asymmetry Calculation
Leslie Ettre discusses peak asymmetry calculation.
The Cleaning and Regeneration of Reversed-Phase HPLC Columns
Ron Majors looks at practical ways to return a contaminated column to its original state.
GC Analysis of Trihalomethanes in Drinking Water — A Rapid and Direct Quantitative Method
The authors describe a GC assay of trihalomethanes in drinking water.
Mobile-Phase Buffers, Part III — Preparation of Buffers
Guest author Tindall's final installment of a three-part series about buffers.
A Leaky Situation
John Hinshaw looks into a carrier-gas leak and its effects on the chromatographic baseline.
A Volatile Ion-Pairing Chromatography Reagent for an LC–MS Mobile Phase
This article presents a volatile ion-pairing reagent that enables good retention of highly polar anionic species using reversed-phase LC–MS.
Polymicro Technologies, LLC
Corporate profile for Polymicro Technologies, LLC. For more information see the company's web site at www.polymicro.com.
Isco, Inc.
Corporate profile for Isco, Inc. For more information see the company's web site at www.isco.com.
Grace Vydac
Corporate profile for Grace Vydac. For more information see the company's web site at www.gracevydac.com.
The Beginnings of Headspace Analysis
Leslie Ettre looks at the birth and early development of headspace analysis.
2002 Index of Authors and Subjects
2002 author–subject index.
Mobile-Phase Buffers, Part II — Buffer Selection and Capacity
In the second part of a three-part series, the guest author discusses selecting buffers for use in partially aqueous mobile phases.
Product Showcase
Products for separation science.
Characterizing Reversed-Phase Column Selectivity
Guest authors Lloyd Snyder and John Dolan describe a method for determining reversed-phase column selectivity.
A Compendium of GC Terms and Techniques
John Hinshaw updates his glossary of GC terms and techniques.
