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Incognito considers the usefulness and scope of the Quality by Design approach to HPLC method development through a question and answer format.

Urine?Diabetic vs. Non-Diabetic Using Statistical Compare - LECO Apps Notes

Protein Deamidation by Cation-Exchange Chromatography - Dionex Apps Note

Joining us for this discussion are Fraser McLeod of Dionex Corporation; Bob McDowall of McDowall Consulting; and Linda Doherty, Dan Holmes, Jeff Louie, and Leon Kopelev of Agilent Technologies, Inc.

The Effect of Water on Low Temperature Heat Transfer Fluid Performance - Paratherm Whitepaper

PerkinElmer (Waltham, Massachusetts) announced that the U.S. Patent & Trademark Office has awarded it a patent titled ?Methods and Systems for Characterizing a Sorbent Tube,? which describes an approach for helping users avoid manual errors in automated thermal desorption (ATD) gas chromatography (GC).

Using solid-phase extraction sorbent followed by LC–MS–MS analysis using HILIC to measure melamine and cyanuric acid in under 3 mins.

The following question and answer were taken from LCGC Europe's "CE Currents" column (1).

It has been announced that Agilent Technologies will pay $1.5 billion, cash, for life sciences consumables and instrumentation supplier, Varian.

One thing all chromatographers know for certain is that, in the words of John Dolan in his April 2006 column, 'It's gonna break.' And when it does, there are a variety of services to choose from in the field of separation science. Our experts explore them here, updating readers on all that is new and innovative in this area.

By now, a reader would have to be living in a log cabin without electricity to be unaware of the acetonitrile shortage currently gripping the chromatography market. The causes, effects, and possible solutions have been documented thoroughly in the pages of LCGC and other industry journals, to the point where the basic facts are common knowledge: the shortage began with (among other factors) the depression of the automobile industry and the consequent reduced production levels. With ACN being a byproduct of this process, its production was reduced as well.

Columnist Michael Balogh looks back on a 1997 LCGC article he wrote, and examines how many technological advances the field of MS has witnessed in the decade since.

New and better software solutions are being created every day in the marketplace, leading to some exciting breakthroughs that promise to make labs and businesses in general more productive.

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A mature technique that is finding new and innovative applications every day, capillary electrophoresis has come to the forefront in much of the recent literature, with the feature article of the August issue of LCGC being dedicated to this technique. We expect that interest in CE will only continue to grow in the future.

From environmental research to petroleum research to testing blood for doping agents, GC remains a workhorse in the field of chromatography. And though other techniques are challenging GC and seeking to dethrone it, none have been completely successful to this point, as GC promises to remain relevant for years to come.

With an ACN shortage gripping the industry, sample prep has become more critical than ever to the productivity of the modern separations lab. Here our experts explore this topic.

With the ACN shortage showing few signs of letting up in the near future, ACN-free methods such as SFC are receiving increased attention and interest. Here our experts discuss this technique.

HPLC and in particular, UHPLC, continue to grow in popularity in the world of separation science, with the UHPLC market predicted to grow 19% by 2012, even in these difficult economic times ("Global Assessment Report," SDi, Inc., 2008).

One of the simplest and most effective techniques in separation science, thin layer chromatography (TLC) continues to find widespread use in the laboratory.

Through a Q & A format, this article illustrates some of the uses of CE in this area.

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Manufacturing operations rely upon chromatography data to ensure product and process quality.

Increases in the speed and sensitivity of MS systems have set new standards in quantitative and qualitative analysis.

SPE is a popular sample preparation technique, valued by analysts working with complex matrices.

This article discusses how chromatographer's toolkits have evolved.

This article describes a new workflow technology in a chromatography data system (CDS) software program. Using this workflow streamlines workflows in chromatography laboratories, enabling users to set-up sequences, process data, and report results in the shortest possible time. This typically speeds up the generation of results, thus, more than matching typical throughput increases found when using UHPLC technology.

As the GC–MS market sees a trend toward high throughput and fast GC analyses, advances in data analysis software must be up to the task.

This article discusses the business benefits of interfacing laboratory applications together to eliminate paper and streamline working practices.

Varian, Inc. has published an application note entitled Light Scattering Analysis of BSA with ProSEC 300S Columns. ProSEC 300S is a silica-based packing with a surface modified for compatibility with proteins, ensuring that true size exclusion is obtained with minimal unwanted interaction affects.