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Many parameters within liquid chromatography–mass spectrometry (LC–MS) methods are "locked and left" - that is, they are optimized using a few methods when new, then only changed if absolutely necessary because of poor analytical performance.

The National Institute of Standards and Technology (NIST).

A recent stimulus to the review process article by the United States Pharmacopoeia (USP) Expert Committee is proposing a major change in the way regulated laboratories develop, validate and control analytical procedures. Is this Quality by Design (QbD) for the chromatography laboratory?

Professor Georges Guiochon spoke to Fabrice Gritti about his pioneering contributions to the field of separation science.

Click the title above to open the LCGC Europe February 2014 regular issue, Vol 27 No 2, in an interactive PDF format.

Click the title above to open the LCGC North America February 2014 Application Notebook, Vol 32 No s2, in an interactive PDF format.

Click the title above to open the LCGC North America February 2014 regular issue, Vol 32 No 2, in an interactive PDF format.

Superficially porous particles for HPLC columns ? often called ?core?shell? particles ? have gotten a lot of attention in recent years because of their excellent performance. Yet so far, columns made with fully porous particles are still the most widely used. Will superficially porous particles eventually take over?

Superficially porous particles for HPLC columns have gotten a lot of attention in recent years because of their excellent performance. Richard Henry discusses why fully porous particles are still the most widely used.

Thermo Fisher Scientific (California, USA) has signed an agreement with GE Healthcare (St Giles, UK) to sell business assets for $1.06 billion. Thermo Fisher committed to sell its cell culture, gene modulation, and magnetic beads businesses in 2013 to expedite approval of its pending acquisition of Life Technologies by the European Commission.

In this new LCGC TV video, Joe Foley briefly explains how sequential LC works and its advantages over conducting multiple runs of conventional LC.

The Supervisory Board of Akzo Nobel N.V (Amsterdam, Netherlands) has announced that Keith Nichols, Chief Financial Officer, will step down from his position at the end of June 2014.

Everyone loves a list. At least, the LCGC editorial team does! LCGC?s biggest stories of the year show just how varied the world of chromatography is. From Excel modeling to evaluating a calibration curve, from trends in sample preparation to poor resolution and sample recovery in UHPLC ? these popular pieces stand for their technical know-how, unique insight, and perspective.

Click here to view the complete E-Separation Solutions newsletter from January 23, 2014.

Gilles Martin, Chairman and Chief Executive Officer of the Eurofins Scientific Group (Luxembourg, Luxembourg), has been elected to the Bruker Board of Directors (Massachusetts, USA). Martin founded the original Eurofins Scientific Nantes food authenticity laboratory in 1988, and is a past President of the French Association of private analytical laboratories, and the North American Technical Committee for Juice and Juice Products.

Superficially porous particles for HPLC columns ? often called ?core?shell? particles ? have gotten a lot of attention in recent years because of their excellent performance. Yet so far, columns made with fully porous particles are still the most widely used. Will superficially porous particles eventually take over?

An assembly of thoughts on all things filtration for HPLC - and how to deal with various nasties - from Rocks to Sand.

Researcher Christina Agapakis from the University of California, Los Angeles, USA, has come up with an unusual way of making cheese by taking bacteria from various parts of the human body and analyzing the odour of each cheese produced using headspace gas chromatography?mass spectrometry (GC?MS).

Scientists in the USA have carried out an investigation into the variety of beverages enjoyed by the Northern Bronze and Iron Age peoples before written records began using a combination of analytical chemical techniques.

The National Institute of Standards and Technology (NIST), an agency of the U.S. Department of Commerce, has made a polycyclic aromatic hydrocarbon (PAH) structure index database publicly available on-line (http://pah.nist.gov/). A byproduct of hydrocarbon fuel combustion, PAHs can have significant adverse health and environmental impacts. The website contains data on more than 650 PAH compounds, with more to be added in the future.

Agilent Technologies (California, USA) has awarded a grant to the Duke Molecular Physiology Institute, Duke University (North Carolina, USA) to support the research of the metabolic and physiological aspects of major chronic diseases such as cardiovascular disease. The institute researchers perform a range of analytical chemistry techniques, including liquid chromatography and gas chromatography coupled to mass spectrometry, to characterize molecular pathways in disease.

In this new video interview, Dwight Stoll of Gustavus Adolphus provides advice about key decisions in method development, common errors to avoid, and other advice for getting started with 2D LC.

The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system.

Agilent Technologies (California, USA) has announced the promotion of Fred Strohmeier, vice president and general manager of Agilent's Life Science Products and Solutions, to senior vice president, Agilent, and president of Agilent's Life Sciences and Diagnostics Group (LDG), effective immediately.

HTC-13

Thermo Fisher Scientific (California, USA) has signed an agreement with GE Healthcare (St Giles, UK) to sell business assets for $1.06 billion. Thermo Fisher committed to sell its cell culture, gene modulation, and magnetic beads businesses in 2013 to expedite approval of its pending acquisition of Life Technologies by the European Commission.

Click here to view the full European E-newsletter from January 9.

A new proteogenomics method using high-resolution isoelectric focusing together with liquid chromatography?mass spectrometry (HiRIEF LC–MS) developed by researchers from Karolinska Institute and Science for Life Laboratory (SciLifeLab) in Sweden has been published in the journal Nature Methods.1

Management culture is stifling automation of analytical methods. Is it time to review the paradigms of your analysis and implement change?

A study published in the Journal of Proteome Research has uncovered some of the proteins responsible for the characteristic aroma and taste of the black P?rigord truffle (Tuber melanosporum Vittad.), using a combined approach of bioinformatics and proteomic analysis.1