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Currently available methods for the detection of matrix effects in liquid chromatography–mass spectrometry (LC–MS) are tedious and complex; therefore, a simpler method is required. Although there are no methods to completely eliminate matrix effects, the most well-recognized technique available to correct for matrix effects is that of internal standardization using stable isotope–labelled versions of the analytes. As this method can prove expensive, an alternative method of correction is likely to be useful. In this study, a simple method based on recovery is assessed for the detection of matrix effects. Two alternative methods for the rectification of matrix effects in LC–MS are also assessed: Standard addition and the coeluting internal standard method.

The mechanisms of mixed-mode chromatography are discussed with reference to the parameters that are used to optimize selectivity and retention. Illustrative examples are presented with strategies for column selection and screening to allow this technique to be quickly and effectively adopted by end users.

There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-directed therapeutic agents for cancer treatment.

Click the title above to open the LCGC Asia Pacific March 2014 regular issue, Vol 17, No 1, in an interactive PDF format.

Click the title above to open the LCGC Europe 2014 regular issue, Vol 27 No , in an interactive PDF format.

Click the title above to open the LCGC North America March 2014 regular issue, Vol 32 No 3, in an interactive PDF format.

Click the title above to open the March 2014 issue of Current Trends in Mass Spectrometry, Volume 12, Number 1, in an interactive PDF format.

By 2020, more than 50% of approved drugs are expected to be protein biopharmaceuticals. Koen Sandra discusses the challenges of characterization and why LC–MS is now indispensable.

The latest newsletter from February 27.

The efficiency of protein separation by ion-exchange chromatography could be increased by up to a factor of 5 according to a new study, potentially speeding up biopharmaceutical production.1 Christy Landes of Rice University in Texas (USA) and her team performed the first molecular-scale investigation into protein ion-exchange chromatography by using direct super-resolution techniques and the stochastic theory.

Lisa A. Holland, of West Virginia University (Morgantown, West Virginia), will preside over this Wednesday morning session.

This Monday afternoon session will be presided over by Stephen G. Weber, of the University of Pittsburgh (Pittsburgh, Pennsylvania).

This morning, the ACS Division of Analytical Chemistry Award for Young Investigators in Separation Science will be presented to Michael Roper of Florida State University.

This morning at 8:30, award sessions will be held for two important awards of strong interest to scientists working in chromatographic and mass spectrometry techniques: The Dal Nogare Award from the Chromatography Forum of the Delaware Valley and the Pittsburgh Conference Achievement Award.

This Tuesday morning oral session will be presided over by Elizabeth Harris, of Mankind Corporation (Valencia, California).

Click here to view the complete E-Separation Solutions newsletter from February 25, 2014.

This Monday morning session will be presided over by Timothy A. Policke of BWXs Technologies.

This Monday morning session will be presided over by Milton L. Lee of Brigham Young University, who also arranged the session.

This Wednesday afternoon session will be presided over by Susan S. Marine of Miami University Middletown.

LCGC, the industry's leading and most-recognized resource for chromatographers, is proud to announce the winners of the 7th Annual Lifetime Achievement and Emerging Leader in Chromatography Awards.

West Table 1

Caroline West Table 2

Click here to view the full European E-newsletter from February 20 2014.

US scientists have developed a new method for an emerging synthetic opioid associated with increased health risks and deaths.

The hills will be alive with the sound of chromatography when the 30th International Symposium on Chromatography (ISC 2014) takes place from 14?18 September 2014 in Salzburg, Austria.

Daniel W. Armstrong, a professor of chemistry and biochemistry at the University of Texas Arlington in Texas (USA) is to receive the 2014 American Chemical Society Award in Separations Science and Technology. This is the second time this year that the ACS has recognized the work of Armstrong – in August last year he was selected to join the ACS Class of Fellows 2013.

The Purdue Research Foundation (Indiana, USA) has awarded $150,000 in investment to two companies that have licensed Purdue University Innovations, Telos Discovery Systems Inc. and bioVidria Inc. The investment is from the Emerging Innovations Fund that was setup in 2008 to accelerate the commercialization of early stage technologies in the Purdue community.

Incognito investigates if changing the carrier gas really requires a full method revalidation.

Daniel W. Armstrong, a professor of chemistry and biochemistry at the University of Texas Arlington in Texas (USA) is to receive the 2014 American Chemical Society Award in Separations Science and Technology. This is the second time this year that the ACS has recognized the work of Armstrong – in August last year he was selected to join the ACS Class of Fellows 2013.

Surrogates, Internal Standards, Isotopically labelled Standards, External Standards, Calibrants, QC Samples etc. etc. - our working lives are littered with checks to ensure that our instruments are giving us the correct results. And rightly so. But do we always use these checks correctly? Do we know what we are checking and why? Indeed, do we know how to design methods/procedures which employ a valid checking regime, often referred to as a Quality System? Let's find out.