Peaks of Interest
The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system.
Patent Granted for Flash Chromatography Technology
The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system. The patent concerns the use of evaporative light scattering detection (ELSD) with flash chromatography. The technology covered in this allowed claim enables streamlined purification of new chemical and biological entities for drug discovery.
Grace previously received similar U.S. patents related to various aspects of flash chromatography using two kinds of detectors, such as ELSD and UV, to collect sample fractions. These techniques improve new molecule purification by increasing recovery, improving reliability, and simplifying instrument operation.
Chris Reddy Receives Award for Oil Spill Research
Chris Reddy, a marine geochemist at the Woods Hole Oceanographic Institution (WHOI) (Woods Hole, Massachusetts), has been selected to receive the 2014 Clair C. Patterson Award from the Geochemical Society. The award recognizes one scientist a year who has made an innovative breakthrough in environmental geochemistry in service to society.
Reddy was nominated for the award because of his work on developing and applying advanced chromatographic and spectrometric techniques to identify the source, transport, and fate of petroleum hydrocarbons in the coastal and open ocean. The award will be presented at Goldschmidt2014 (Sacramento, California) in June 2014.
"One of my overarching interests in studying oil spills is that there are compounds in oil that seem to persist a very long time while there are others that can disappear quickly. I find it fascinating that a spectrum like this exists," said Reddy. He added: "Clair C. Patterson was a tenacious trailblazer in studying lead and lead pollution. For me to be associated with him is, quite frankly, humbling."
Jeff Seewald, chair of WHOI's Department of Marine Chemistry and Geochemistry said: "His application and development of innovative analytical approaches have resulted in a quantum leap in our ability to predict the persistence of anthropogenic and naturally occurring petroleum in the marine environment."
Seewald added: "Chris is motivated by a strong desire to understand the consequences of human activity on the environment and has a special gift for communicating relevant information to the scientific community, policy makers, and the general public."
New Study Uses MSPE with GC–MS to Analyze PFCAs in Water
January 20th 2025Scientists from the China University of Sciences combined magnetic solid-phase extraction (MSPE) with gas chromatography–mass spectrometry (GC–MS) to analyze perfluoro carboxylic acids (PFCAs) in different water environments.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ion used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
A Guide To Finding the Ideal Syringe and Needle
January 20th 2025Hamilton has produced a series of reference guides to assist science professionals in finding the best-suited products and configurations for their applications. The Syringe and Needle Reference Guide provides detailed information on Hamilton Company’s full portfolio of syringes and needles. Everything from cleaning and preventative maintenance to individual part numbers are available for review. It also includes selection charts to help you choose between syringe terminations like cemented needles and luer tips.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Oasis or Sand Dune? Isolation of Psychedelic Compounds
January 20th 2025Magic mushrooms, once taboo, have recently experienced a renaissance. This new awakening is partially due to new findings that indicate the effects of psilocybin, and its dephosphorylated cousin psilocin may produce long lasting results for patients who might be struggling with anxiety, depression, alcohol and drug abuse, and post-traumatic stress disorder. Hamilton Company has developed a methodology for the isolation and identification of 5 common psychedelic compounds used in the potential treatment of disease. The PRP-1 HPLC column resin remains stable in the harsh alkaline conditions ideal for better separations.
