Peaks of Interest
The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system.
Patent Granted for Flash Chromatography Technology
The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system. The patent concerns the use of evaporative light scattering detection (ELSD) with flash chromatography. The technology covered in this allowed claim enables streamlined purification of new chemical and biological entities for drug discovery.
Grace previously received similar U.S. patents related to various aspects of flash chromatography using two kinds of detectors, such as ELSD and UV, to collect sample fractions. These techniques improve new molecule purification by increasing recovery, improving reliability, and simplifying instrument operation.
Chris Reddy Receives Award for Oil Spill Research
Chris Reddy, a marine geochemist at the Woods Hole Oceanographic Institution (WHOI) (Woods Hole, Massachusetts), has been selected to receive the 2014 Clair C. Patterson Award from the Geochemical Society. The award recognizes one scientist a year who has made an innovative breakthrough in environmental geochemistry in service to society.
Reddy was nominated for the award because of his work on developing and applying advanced chromatographic and spectrometric techniques to identify the source, transport, and fate of petroleum hydrocarbons in the coastal and open ocean. The award will be presented at Goldschmidt2014 (Sacramento, California) in June 2014.
"One of my overarching interests in studying oil spills is that there are compounds in oil that seem to persist a very long time while there are others that can disappear quickly. I find it fascinating that a spectrum like this exists," said Reddy. He added: "Clair C. Patterson was a tenacious trailblazer in studying lead and lead pollution. For me to be associated with him is, quite frankly, humbling."
Jeff Seewald, chair of WHOI's Department of Marine Chemistry and Geochemistry said: "His application and development of innovative analytical approaches have resulted in a quantum leap in our ability to predict the persistence of anthropogenic and naturally occurring petroleum in the marine environment."
Seewald added: "Chris is motivated by a strong desire to understand the consequences of human activity on the environment and has a special gift for communicating relevant information to the scientific community, policy makers, and the general public."
GC–TOF-MS Finds 250 Volatile Compounds in E-Cigarette Liquids
November 1st 2024A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Multivariate Design of Experiments for Gas Chromatographic Analysis
November 1st 2024Recent advances in green chemistry have made multivariate experimental design popular in sample preparation development. This approach helps reduce the number of measurements and data for evaluation and can be useful for method development in gas chromatography.
