Sense and Sensitivity: The Role of Separation Science in Sensory Evaluation
April 14th 2014LCGC spoke to Giorgia Purcaro of the Department of Food Science at the University of Udine, Italy, and Chiara Cordero of the Department of Drug Science and Technology at the University of Turin, Italy, about the sensory evaluation of olive oil and the benefits of a comprehensive approach.
Eberhard Gerstel Prize Awarded to Jakob Haun
April 10th 2014The Working Group Separation Sciences of the Analytical Division of the German Chemical Society has awarded the Eberhard Gerstel Prize to Jakob Haun, a doctoral student at the Institute for Energy and Environmental Technology (Duisburg, Germany) for an outstanding research publication.
GC–MS Detects and Identifies Four Ozone Depleting Gases in Atmosphere
April 8th 2014Four new ozone-depleting substances (ODSs) - CFC–1121, CFC–112a, CFC–113a, and HCF–133a - have been detected and identified in the Earth's atmosphere using gas chromatography–mass spectrometry (GC–MS).1 The research published in Nature Geoscience compared samples collected between 1978 and 2012 to establish a clear increase in the emissions of these gases, even though CFC production has been banned globally since 1987.
LC–MS–MS Approach to Aid the Optimization of Biopharmaceutical Immunogenicity Assays
April 8th 2014Scientists from Bristol-Myers Squibb Company have developed a novel approach for the simultaneous quantitation of neutralizing antibodies, residual drug, and human Immunoglobulin G (IgG) in immunogenicity assay development using liquid chromatography–tandem mass spectrometry (LC–MS–MS). This work published in Analytical Chemistry presents a new approach that aids the refinement of therapeutic protein neutralizing antibody assays in drug development
Tips & Tricks GPC/SEC: Mobile Phase Considerations
April 8th 2014There are many sources of advice on how to select the most appropriate stationary phase for sample analysis, but the mobile phase is not often discussed. This article provides tips for selecting the most appropriate mobile phase for your analysis.
UHPLC Method Development and Modelling in the Framework of Quality by Design
April 8th 2014The goals in ultrahigh-pressure liquid chromatography (UHPLC) method development are to first find the best separation, second find the best column, and third find the most robust method in a multifactorial Design Space. Trial and error methods are not sufficient anymore and solid science based on Quality by Design (QbD) principles is required.
LC–MS Approach to Aid the Optimization of Biopharmaceutical Immunogenicity Assays
April 3rd 2014Scientists from Bristol-Myers Squibb Company have developed a novel approach for the simultaneous quantitation of neutralizing antibodies, residual drug, and human Immunoglobulin G (IgG) in immunogenicity assay development using liquid chromatography?tandem mass spectrometry (LC–MS–MS). This work published in Analytical Chemistry presents a new approach that aids the refinement of therapeutic protein neutralizing antibody assays in drug development.
Impact of New Columns on Drug Development
April 1st 2014An examination of the development of new types of columns based on different particle types, sizes, and other physical characteristics and how they can improve the speed and efficiency of HPLC used to support more expansive and complicated analyses