Gerard Rozing Wins 2014 Uwe D. Neue Award
March 13th 2014Gerard Rozing has been announced as the winner of the second annual Uwe D. Neue Award in Separation Science. The award was created by Waters Corporation (Massachusetts, USA) to recognize the work of distinguished industrial scientists, in honour of Dr Uwe D. Neue, late scientist and Waters Corporate Fellow. Rozing will receive the award at the upcoming 41st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC2014) held on 11–15 May in New Orleans, USA.
The LCGC Blog: A View of Separation Science Research at a Czech Conference
March 13th 2014The United States woefully underfunds international collaborations with the Czech Republic. Yet, it is a country that produces excellent scientists who are distinctly passionate about science, and who have been educated to demonstrate not only a strong mastery of chemistry basics, but also superb knowledge of the integration of high-level mathematics and computer programming skills into their science. One need not look very far in the separation science and mass spectrometry (MS) fields in the United States to find eminent leaders with roots in the Czech Republic.
Principal Component Analysis with LC–MS Enhances Natural Drug Discovery Process
March 10th 2014Scientists in Malaysia have developed a useful metabolomics approach that could aid analysts working in natural drug discovery. The team applied liquid chromatography–mass spectrometry (LC–MS) coupled with principle component analysis (PCA) to screen more than 4000 natural extracts for novel photosensitizer drugs.
Gerstel Form OEM Agreement with Spark Holland
March 6th 2014Gerstel GmbH & Co. KG (M?lheim an der Ruhr, Germany) and Spark Holland (Emmen, The Netherlands) have announced an original equipment manufacturer (OEM) agreement. The agreement will allow Gerstel to develop and market fully integrated automated dried blood spot (DBS) technology from Spark Holland that recently received a US patent.
Myths in Ultrahigh-Pressure Liquid Chromatography
March 1st 2014The advent of ultrahigh-pressure liquid chromatography (UHPLC) and its successful commercialization in the last few years has brought forth a modern high performance liquid chromatography (HPLC) platform capable of higher speed, resolution, precision, and sensitivity. Currently, all major HPLC manufacturers have some type of low-dispersion UHPLC products with upper pressure limits ranging from 15,000 to 19,000 psi (1000 to 1300 bar) on the market. This installment describes a number of popular myths or half-truths in UHPLC and provides data that contradict or even repudiate some of these commonly held beliefs.
Strategies for the Detection and Elimination of Matrix Effects in Quantitative LC–MS Analysis
March 1st 2014Currently available methods for the detection of matrix effects in liquid chromatography–mass spectrometry (LC–MS) are tedious and complex; therefore, a simpler method is required. Although there are no methods to completely eliminate matrix effects, the most well-recognized technique available to correct for matrix effects is that of internal standardization using stable isotope–labelled versions of the analytes. As this method can prove expensive, an alternative method of correction is likely to be useful. In this study, a simple method based on recovery is assessed for the detection of matrix effects. Two alternative methods for the rectification of matrix effects in LC–MS are also assessed: Standard addition and the coeluting internal standard method.