Application Notes

This work is focused on the development of a novel SARS-CoV-2 spike glycoprotein assay based on BAMS™ assay platform with detection by MALDI-TOF MS.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) for better characterization of the Fc fragment.

Report of verified results for pesticide residues sensitivity in food using the JMS-TQ4000GC

Selectivity of two high-pH stable Agilent InfinityLab Poroshell 120 C18 columns is compared with pesticides using a pH 10 formate buffer and acetonitrile gradient.

This application combines cysteine proteases IgdE and IdeS, to observe conserved and hypervariable regions of the antibody, as well as identification of other variants.

Pesticides in a hemp matrix were analyzed using the SRM capabilities of the JEOL JMS-TQ4000GC gas chromatograph triple-quadrupole mass spectrometer.

Report of the stability of eight pesticides that were added to a spinach extract, with good reproducibility

Pesticides in Cannabis sativa matrix were analyzed using the SRM capabilities of the JEOL JMS-TQ4000GC gas chromatograph triple-quadrupole mass spectrometer.

IgdE allows for better characterization of the antibody and yields an intact Fc and an intact Fab fragment that can be further isolated and characterized.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection, separation of low-level impurities for subunit analysis.

Quantitative analysis of residual agricultural chemicals in carrot extract was undertaken using a JEOL JMS-TQ4000GC.

A reversed-phase method using a superficially porous, wide pore particle morphology for the quantitation of coformulated mAbs leads to high efficiency separations.

For LC–MS analysis of NIST mAb, multiple C4 LC columns are compared to determine which provides necessary separation of impurity and avoids spectral overlap in the MS detector.

The performance of basic pharmaceuticals is compared to the charged surface Agilent InfinityLab Poroshell 120 CS-C18 and a C18 with formic acid mobile phase.

For Fc Fusion proteins a reversed-phase LC analytical method is used for either extended characterization and identification for impurities or as a simple purity method.

Loading capacity and peak shape of basic pharmaceuticals were compared on the Agilent InfinityLab Poroshell 120 CS-C18 and a traditional C18 column with formic acid.

Quantitative analysis of residual agricultural chemicals in spinach extract was undertaken using a JEOL JMS-TQ4000GC.

Intact reversed-phase LC method is implemented for a simple yet high-resolution analytical technique that can be used for the purity analysis of monoclonal antibodies.

This white paper provides a vendor’s perspective on recent trends in regulations and the potential future direction for the industry referred to as “Pharma 4.0”.

Analyzing diverse method parameters, such as temperature, gradient program, and flow rates for optimization of intact mass applications when using bioZen WidePore C4.

The value of a wide range of pH compatibility is explored. A pesticide mixture shows how eluent pH affects analyte retention for acids, bases, and neutrals.

The unique selectivity of four Agilent InfinityLab Poroshell 120 C18 columns is shown with veterinary drugs using a simple formic acid and acetonitrile gradient.

PerkinElmer’s Clarus® GC systems’ wide-range FID measures hydrocarbon compounds at very low and very high levels.

In this application note, a method for the analysis of TMA in the exhaust gas of a station pollution source is presented.

A simple, rapid, sensitive, and cost-effective LC–MS/MS method has been applied and validated for the analysis of 17 PFASs in real water samples with good accuracy.

Rapid LC–MS/MS method for the separation and detection of 44 drug of abuse compounds, including cocaine, LSD, marijuana, morphine, and heroin

Methods for the separation, detection, and quantitation of complex polar contaminants such as trifluoracetic acid, metformin, glyphosate, chlorate, and bromate by UHPLC–MS/MS

Explosives and related materials were collected using Custodion SPME and CME syringes and identified on a Torion T-9 Portable GC/MS.

Evaluating analytes in drinking water following U.S. EPA 200.8 with reduction in sample analysis time using HTS introduction system integrated with NexION® ICP-MS, Syngistix™