Application Notes

The Torion® T-9 GC/MS system has characterized several high boiling point organochlorine pesticides in tea samples in less than 10 minutes.

This application note discusses using a Quasar™ C18 column to analyze azithromycin, an antibiotic used to treat various bacterial infections.

SPME-UHPLC/MS/MS offers an efficient alternative for the analysis of veterinary drug residues in animal tissue as compared to traditional sampling procedures.

The Quasar biphenyl HPLC phase offers high efficiency separation and excellent peak shape of the synthetic antibiotic, ciprofloxacin.

This application note describes using a Quasar biphenyl LC column in analyzing several cephalosporins, a mixture of first and second generation β-lactam antibiotics.

FFF-MALS-DLS provides the detailed characterization of nano-pharmaceuticals that is essential for development and regulatory filing.

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

This work is focused on the development of a novel SARS-CoV-2 spike glycoprotein assay based on BAMS™ assay platform with detection by MALDI-TOF MS.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) for better characterization of the Fc fragment.

Report of verified results for pesticide residues sensitivity in food using the JMS-TQ4000GC

Selectivity of two high-pH stable Agilent InfinityLab Poroshell 120 C18 columns is compared with pesticides using a pH 10 formate buffer and acetonitrile gradient.

This application combines cysteine proteases IgdE and IdeS, to observe conserved and hypervariable regions of the antibody, as well as identification of other variants.

Pesticides in a hemp matrix were analyzed using the SRM capabilities of the JEOL JMS-TQ4000GC gas chromatograph triple-quadrupole mass spectrometer.

Report of the stability of eight pesticides that were added to a spinach extract, with good reproducibility

Pesticides in Cannabis sativa matrix were analyzed using the SRM capabilities of the JEOL JMS-TQ4000GC gas chromatograph triple-quadrupole mass spectrometer.

IgdE allows for better characterization of the antibody and yields an intact Fc and an intact Fab fragment that can be further isolated and characterized.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection, separation of low-level impurities for subunit analysis.

Quantitative analysis of residual agricultural chemicals in carrot extract was undertaken using a JEOL JMS-TQ4000GC.

A reversed-phase method using a superficially porous, wide pore particle morphology for the quantitation of coformulated mAbs leads to high efficiency separations.

For LC–MS analysis of NIST mAb, multiple C4 LC columns are compared to determine which provides necessary separation of impurity and avoids spectral overlap in the MS detector.

The performance of basic pharmaceuticals is compared to the charged surface Agilent InfinityLab Poroshell 120 CS-C18 and a C18 with formic acid mobile phase.

For Fc Fusion proteins a reversed-phase LC analytical method is used for either extended characterization and identification for impurities or as a simple purity method.

Loading capacity and peak shape of basic pharmaceuticals were compared on the Agilent InfinityLab Poroshell 120 CS-C18 and a traditional C18 column with formic acid.

Quantitative analysis of residual agricultural chemicals in spinach extract was undertaken using a JEOL JMS-TQ4000GC.

Intact reversed-phase LC method is implemented for a simple yet high-resolution analytical technique that can be used for the purity analysis of monoclonal antibodies.

This white paper provides a vendor’s perspective on recent trends in regulations and the potential future direction for the industry referred to as “Pharma 4.0”.

Analyzing diverse method parameters, such as temperature, gradient program, and flow rates for optimization of intact mass applications when using bioZen WidePore C4.