Application Notes

How to use of size-exclusion chromatography (SEC) and hydrophobic interaction chromatography (HIC) for the analysis of camelid single-domain antibodies (nanobodies).

By using optimized reagents and method conditions, learn how to reduce 2-AB labeling of glycans from days to just two hours.

Learn how to perform method optimization using a bio-inert quaternary LC instrument to screen multiple mobile-phase compositions for aggregate analysis of NIST mAb.

Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic drugs that demonstrate effectiveness on gene silencing through RNA interference (RNAi).

We present retention-time models for peptides and proteins that link their elution times to solvent fraction and temperature.

Learn how impurity-monitoring software can improve your understanding of your process route and help you track fate and purge.  

This application note shows the analysis of melamine migration from bamboo cups using hydrophilic interaction liquid chromatography (HILIC).

This application note shows the analysis of melamine migration from bamboo cups using hydrophilic interaction liquid chromatography (HILIC).

Adsorption of metal-sensitive analytes in LC-based assays can negatively impact data. Learn how to minimize analyte–surface interaction and improve reproducibility.

The ALEXYS Carbohydrates Analyzer is a robust and reliable solution for the analysis of carbohydrates in apple juice, buttermilk, malt beer, and artificial sweeteners.

We discuss the theory, principles, and key equations required for method translation for both isocratic and gradient LC methods using the Avantor® ACE® Method Translator tool.

In this application note, we present data on the separation of native gluten using asymmetrical flow field-flow fractionation (AF4) with no sample pre-treatment, which can provide a more direct measurement of their molecular weight and radius of gyration (Rg) distributions.

This study describes the separation of nanoplastics and determination of their surface charge by electrical asymmetrical flow field-flow fractionation.

In this application note, we demonstrate the use of thermal field-flow fractionation (TF3) for the characterization of acrylic polymers.