Welcome to Day 2 of HPLC 2010
Good Morning and welcome to Day 2 of LCGC's continuing coverage of HPLC 2010. We hope you've been able to take in some of the sights and sounds of Boston, Massachusetts, in addition to attending the many technical sessions and exhibitor booths at this year's conference.
Good Morning and welcome to Day 2 of LCGC's continuing coverage of HPLC 2010. We hope you’ve been able to take in some of the sights and sounds of Boston, Massachusetts, in addition to attending the many technical sessions and exhibitor booths at this year’s conference. If not, you still have plenty of time, as Faneuil Hall, Boston Common, and yes, HPLC 2010 and the Hynes Convention Center won’t be going anywhere any time soon. However, unfortunately, the sport that Boston is most associated with will not be played this week, as the Red Sox are out of town. But never fear: You can strike up a conversation with just about any cab driver or street vendor if you’d like to talk baseball and find out how Boston’s team is doing. They’ll be more than happy to oblige you.
As for chromatography, discussions on this topic will not be in short supply either, as today’s schedule is loaded with informative sessions delivered by the industry’s most well-known figures. Today’s docket is also full of familiar faces from the pages of LCGC, and in particular, I would recommend taking in “Multidimensional Separations I” in Ballroom C this morning at 9 am. Chaired by LCGC EAB member and industry veteran Peter Carr, this session will have presentations from frequent LCGC authors Mark Schure (“Measuring the Dimensionality of Separation Systems: A New Performance Metric for Chromatography”) and Pavel Jandera (“Gradient Optimization in two-Dimensional Comprehensive LCXLC”). Readers can also look for a nostalgic look at the field of chromatography from Dr. Carr in the August issue of LCGC, as he recounts his time in the industry and offers some amusing anecdotes from the “old days.”
In the meantime, we would also like to once again extend our personal invitation to stop by the LCGC booth (#414) any time and say hello. Not only do we want to hear your feedback on the show and LCGC, but we also have some diehard baseball fans on our staff, so you may be able to kill two birds with one stone. Enjoy the show today!
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
