Wednesday Afternoon Session on Biopharmaceuticals Analysis
This parallel session, entitled “Biopharmaceuticals: Forward Looking,” is co-chaired by Peter Yehl of Genentech, Inc. and Samuel Foster of Rowan University in Glassboro, New Jersey, USA. It will be held from 3:45 to 6:00 pm in the Palm Rooms 1-2-3.
Kicking off the session, Cong Bi of Bristol-Meyers Squibb will present a keynote lecture titled “Development and Optimization of a Robust HPLC Method for Analytical Process Control of a Pharmaceutical Intermediate.”
Following at 4:15, will be Sissi White of Thermo Fisher Scientific delivering a keynote lecture about the characterization of lipid nanoparticle (LNP) composition using ultrahigh-pressure liquid chromatography with charged aerosol detection (UHPLC–CAD).
At 4:45, Jean-Marc Roussel of JM Rousell Consulting will present a keynote lecture titled “Improving the Interpretation of Robustness Studies: Managing the Leap into the Real World.”
Next, at 5:15, Shanhua Lin of Thermo Fisher Scientific will present new insights into the chromatography mechanisms of ion-exchange charge variant analysis, during which a discussion about dispelling myths and providing guidance for robust method optimization will take place.
The following presentation will be given at 5:30 and will be led by Stephen Groskreutz of Eli Lilly and Company. The talk is titled “Continuous Manufacturing of Tirzepatide using Online UHPLC-based PAT: An Enabling Technology for Commercialization of a Synthetic Peptide.”
The final presentation will be led by Georgy Cooney of S-Matrix Corporation Inc. Cooney will describe QbD experimentation supporting all stages of analytical procedure lifecycle management (APLM) with the Fusion Qbd software.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
