Universal HPlC
High-pressure ion chromatography uses small-particle-size columns for fast, high resolution analyses. The Thermo Scientific? Dionex? ICS-5000+ HPIC? system operates at high pressures over its entire flow rate range.
High-pressure ion chromatography enables the use of small-particle-size IC columns for fast analyses and high resolution. The Thermo ScientificTM DionexTM ICS-5000+ HPICTM system is the first system with an all-PEEKTM flow path capable of operating continuously at high system pressures over its entire flow rate range. High backpressure tolerance lets you increase flow rates to maximize your throughput while still benefiting from the advantages of electrolytic eluent generation and suppression. Sensitivity, resolution, and ease-of-use are taken to a whole new level. New 4 μm particle-size columns take full advantage of the broad flow/pressure range, enabling fast, high-resolution separations in challenging matrices. See peaks you’ve been missing before with the high-resolution, 250 mm long columns, or increase throughput with our fast 150 mm columns.
Learn more at thermoscientific.com/ics5000+ and analyze@thermofisher.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
