Tuesday Afternoon Session: Nano-Scale and Microfluidic Separations and Mass Spectrometry
This Tuesday afternoon session (TOB) will take place from 2:30?4:30 p.m. in room 307-308. The session will be presided over by Bryan Fonslow of Scripps Research Institute.
This Tuesday afternoon session (TOB) will take place from 2:30–4:30 p.m. in room 307-308. The session will be presided over by Bryan Fonslow of Scripps Research Institute.
The first talk in this session is titled “Next Generation Blood Sampling For Mass Spectral Analysis Of Proteins and Metabolites” and will be presented by Fred E. Regnier of Purdue University in West Lafayette, Indiana. Regnier is the recipient of the 2014 LCGC Lifetime Achievement in Chromatography Award as well as a member of LCGC’s editorial advisory board.
The second talk will be given by John A. Mclean of Vanderbilt University in Nashville, Tennessee. Mclean’s talk is titled “Peering into Biology from the Outside: Exometabolic Microfluidics-Based Platforms Integrated with Structural Mass Spectrometry for Systems, Synthetic, and Chemical Biology.”
Next, Barry L. Karger of the Barnett Institute at Northeastern University in Boston, Massachusetts will present. Karger’s talk is titled “High Peak Capacity Ultranarrow PLOT LC Columns Coupled to Mass Spectrometry for Proteomic Analysis of Vanishingly Small Samples.”
“High Resolution HILIC for Proteomic LC-MS” is the next talk on the schedule. Yasushi Ishihama of Kyoto University in Kyoto, Japan will present this.
Liangliang Sun of the University of Notre Dame in South Bend, Indiana will present next. Sun’s talk is titled “Capillary Zone Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry for Highly Sensitive Shotgun Proteomics.”
The final talk in this session is titled “A Hybrid Microchip/Capillary Electrophoresis Mass Spectrometry Platform for Rapid and Ultrasensitive Bioanalysis.” This talk will be given by Keqi Tang of Pacific Northwest National Laboratory in Richland, Washington.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Frontage Laboratories Streamlines their Product Lifecycle Management with NuGenesis™ LMS
January 9th 2025Frontage laboratories wanted to improve the efficiency and quality of their operations and invest in ways to streamline their workflows. They implemented Waters NuGenesis™ Lab Management System (LMS) to progress their digital transformation journey and combine synergistic data, workflow, and sample management capabilities to support the entire product lifecycle from discovery through manufacturing.
The Intricacies of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
