Thermo Fisher Scientific Inc. and SRI International have announced they will be collaborating to enhance small molecule research.
Thermo Fisher Scientific Inc. (San Jose, California, USA) and SRI International (Menlo Park, California, USA) have announced they will be collaborating to enhance small molecule research.
The collaboration will allow researchers a direct link between Thermo’s Scientific Compound Discover 2.1 software platform and SRI international’s BioCyc, a collection of 9300 databases that provide electronic reference sources on the metabolic pathways and genomes of many organisms. This will enable automatic and interactive overlay of statistic data onto these pathways, and facilitate the biological interpretation of results obtained from a metabolomics experiment.
“Today, metabolomics researchers can measure thousands of small molecules, but it can be challenging to know which cellular systems are behaving differently in the studied condition compared to a control,” said Andreas Huhmer, director of proteomics and metabolomics marketing, chromatography and mass spectrometry at Thermo Fisher Scientific.
“The new integration will allow scientists using [the software platform] to automatically map the most detected compounds to BioCyc metabolic pathway diagrams, and to connect additional experimental data, such as relative abundance or differential expression, onto the pathways,” continued Huhmer.
Information from the collaboration was presented at the 13th Annual Conference of the Metabolomics Society on 25–29 June 2017 in Brisbane, Australia.
For more information please visit: www.thermofisher.com and www.sri.com
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
Liquid Chromatography to Analyze Vitamin D Proteins in Psoriasis Patients
January 21st 2025Can a protein involved in delivering Vitamin D to target tissues have an altered serum profile in psoriasis patients with cardiovascular disease? Researchers used liquid chromatography (LC) to help find out.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
A Guide To Finding the Ideal Syringe and Needle
January 20th 2025Hamilton has produced a series of reference guides to assist science professionals in finding the best-suited products and configurations for their applications. The Syringe and Needle Reference Guide provides detailed information on Hamilton Company’s full portfolio of syringes and needles. Everything from cleaning and preventative maintenance to individual part numbers are available for review. It also includes selection charts to help you choose between syringe terminations like cemented needles and luer tips.