Researchers Discover Sex Hormone-Binding Globulin Shows Link to Fracture Risk in Older Men
Researchers from the University of Gothenburg and other sites in Sweden, along with researchers from Portland, Oregon and Quebec, Canada conducted a study to examine the role of serum sex steroids in fracture risk among men.
Researchers from the University of Gothenburg and other sites in Sweden, along with researchers from Portland, Ore. and Quebec, conducted a study to examine the role of serum sex steroids in fracture risk among men. The study included 2,639 men with a mean age of 75 years from MrOS Sweden, a prospective, population-based cohort. The researchers used a specific gas chromatography–mass spectrometry technique to analyze sex steroids at baseline. After baseline, the incidence of at least one fracture was 20.9 per 1,000 person-years. The researchers found an inverse relationship between fracture risk and estradiol (HR per standard deviation decrease=1.34), free estradiol (HR per SD decrease=1.41), testosterone (HR per SD decrease=1.27), and free testosterone (HR per SD decrease=1.32). However, sex hormone–binding globulin was directly related to fracture risk (HR per SD decrease=1.41), according to the researchers.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
