Researchers Develop New Method for Drug Testing
U.S. researchers have developed a new LC–MS-MS method that is more sensitive for detecting if athletes have taken drugs to artificially boost testosterone and increase physical performance.
U.S. researchers have developed a new LC–MS-MS method that is more sensitive for detecting if athletes have taken drugs to artificially boost testosterone and increase physical performance. Previous testing methods used GC–MS to compare the ratio of testosterone to epitestosterone and determine if performance-enhancing drugs were taken. However, measuring the T/E concentrations is difficult due to the low levels present in urine.
According to the lead researcher, Dr. Jonathan Danaceau of the University of Utah, the new method "means that we can determine the T/E ratio in a sample with greater confidence, and therefore be in a better position to spot doping violations without falsely accusing innocent athletes."
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December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
