From the Publisher
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular.
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular. Many issues that dominated the headlines just a few short months ago have now evolved and given way to new issues that may require new solutions.
Michael J. Tessalone
At LCGC, we continue to believe as we always have, that the notes contained in The Application Notebook are something of a microcosm of the marketplace, reflecting the ongoing and evolving issues that face chromatographers every day, and this edition is no exception. With the biotech industry continuing to make strides, you will see numerous application notes across this field, including many on biopharmaceuticals. With concerns over the long-term price of acetonitrile now beginning to replace supply considerations in many minds, you will find notes that offer new and innovative ways to conserve solvent. With food safety continuing to be a major concern in the U.S. and world markets, more stringent testing is being implemented, and here you will find corresponding application notes with new and better food testing methods, created in large part to meet this challenge.
In short, if you are experiencing an issue in your lab or business, chances are you will find it being addressed in one of the application notes contained in this issue. And if by some chance you do not, then please feel free to let us know. We rely on your feedback to help us shape future content and projects down the road, so do not hesitate to contact myself or any of our staff at the listings found in the masthead.
Enjoy the issue.
Michael J. Tessalone
Science Group Publisher
Critical Role of Oligonucleotides in Drug Development Highlighted at EAS Session
November 19th 2024A Monday session at the Eastern Analytical Symposium, sponsored by the Chinese American Chromatography Association, explored key challenges and solutions for achieving more sensitive oligonucleotide analysis.
6PPD-Quinone Reference Materials
November 19th 2024Ensure environmental and consumer health with our standards for 6PPD-quinone testing. 6PPD-quinone has been detected in the environment and has shown toxicity to aquatic life. Chiron, by Zeptometrix® offers reference standards suitable for Draft EPA Method 1634.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Microplastics Reference Materials
November 19th 2024The World’s First Microplastics Reference Materials. Our scientists have focused on these emerging global threats, and are excited to share Chiron MicroPrefs®, the first commercial microplastic reference material. The MicroPref® portfolio is designed to detect the six most abundant plastics in the environment and is available in a novel, easy-to-use tablet formulation. Be among the first labs to join in the fight against microplastic pollution by exploring the NEW line of Chiron MicroPrefs® microplastic standards.
RAFA 2024 Highlights: Cutting-Edge Chromatography Techniques for Food Safety and Food Analysis
November 18th 2024An illuminating session focusing on progress in analytical techniques used in food analysis took place on Wednesday 6 November 2024 at RAFA 2024 in Prague, The Czech Republic, including a talk on the analysis of 1000 toxins in 10 minutes.
