From the Publisher
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular.
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular. Many issues that dominated the headlines just a few short months ago have now evolved and given way to new issues that may require new solutions.
Michael J. Tessalone
At LCGC, we continue to believe as we always have, that the notes contained in The Application Notebook are something of a microcosm of the marketplace, reflecting the ongoing and evolving issues that face chromatographers every day, and this edition is no exception. With the biotech industry continuing to make strides, you will see numerous application notes across this field, including many on biopharmaceuticals. With concerns over the long-term price of acetonitrile now beginning to replace supply considerations in many minds, you will find notes that offer new and innovative ways to conserve solvent. With food safety continuing to be a major concern in the U.S. and world markets, more stringent testing is being implemented, and here you will find corresponding application notes with new and better food testing methods, created in large part to meet this challenge.
In short, if you are experiencing an issue in your lab or business, chances are you will find it being addressed in one of the application notes contained in this issue. And if by some chance you do not, then please feel free to let us know. We rely on your feedback to help us shape future content and projects down the road, so do not hesitate to contact myself or any of our staff at the listings found in the masthead.
Enjoy the issue.
Michael J. Tessalone
Science Group Publisher
New Study Uses MSPE with GC–MS to Analyze PFCAs in Water
January 20th 2025Scientists from the China University of Sciences combined magnetic solid-phase extraction (MSPE) with gas chromatography–mass spectrometry (GC–MS) to analyze perfluoro carboxylic acids (PFCAs) in different water environments.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ion used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
A Guide To Finding the Ideal Syringe and Needle
January 20th 2025Hamilton has produced a series of reference guides to assist science professionals in finding the best-suited products and configurations for their applications. The Syringe and Needle Reference Guide provides detailed information on Hamilton Company’s full portfolio of syringes and needles. Everything from cleaning and preventative maintenance to individual part numbers are available for review. It also includes selection charts to help you choose between syringe terminations like cemented needles and luer tips.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Oasis or Sand Dune? Isolation of Psychedelic Compounds
January 20th 2025Magic mushrooms, once taboo, have recently experienced a renaissance. This new awakening is partially due to new findings that indicate the effects of psilocybin, and its dephosphorylated cousin psilocin may produce long lasting results for patients who might be struggling with anxiety, depression, alcohol and drug abuse, and post-traumatic stress disorder. Hamilton Company has developed a methodology for the isolation and identification of 5 common psychedelic compounds used in the potential treatment of disease. The PRP-1 HPLC column resin remains stable in the harsh alkaline conditions ideal for better separations.
