Process & Mass Spectrometers
A Tuesday session on process and mass spectrometers begins at 9:00 am and takes place in Room 370 D at the George R. Brown Convention Center in Houston, Texas.
A Tuesday session on process and mass spectrometers begins at 9:00 am and takes place in Room 370 D at the George R. Brown Convention Center in Houston, Texas.
The first presentation, to be given by Ernie Hillier of Waters Corporation, will look at how modern HPLC with 1/10 the analysis time makes process HPLC realistic. An in depth collaboration between instrument development scientists and process engineers identified specific obstacles to the implementation of liquid chromatography as a process analytical technology tool.
At 10:00 am, Chuck De Carlo of Extrel CMS will discuss real-time refinery fenceline benzene using a process mass spectrometer. The talk will focus on how real-time monitoring is safer for the community and, combined with wind direction, can rapidly indicate transient benzene from neighboring industrial facilities, highways, rail lines, and other areas.
“Hand Portable GC/MS Technologies for Rapid Response Field Analysis” will be discussed next, starting at 10:30 am. Leeman Bennington of PerkinElmer will talk about product evolution, GC characteristics, MS design and theory, software considerations, quick sampling techniques, and proven applications.
Next, at 11:00 am, Barry J. Prince of Syft Technologies will look at high temporal resolution mud-gas analysis using selected-ion flow tube mass spectrometry (SIFT-MS). SIFT-MS is an analytical technique that detects and quantifies volatile organic compounds directly in air to part-per-trillion concentrations within seconds.
Joshua Whiting of APIX Analytics will follow at 1:00 pm with a presentation on a modular approach for rapid on-line GC analysis in potentially explosive atmospheres (ATEX zone 1 and CEC/NA class 1/Div1). The discussion will focus on a system developed by APIX Analytics that is capable of simultaneously analyzing permanent gases, heavier hydrocarbons, VOCs and sulfur compounds with a single sample collection.
The final talk will start at 1:30 pm and will be given by Andrew J. Jones of Activated Research Company. Jones will compare the analyses of several mixtures using GC with FID, MS, and Polyarc/FID and show how the universal carbon response and large linear dynamic range of the Polyarc/FID can lead to better data quality, integrity, and reliability in less time.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
