Leading lights in TOC
Shimadzu Product Profile
Shimadzu’s new TOC-L Series combines the proven combustion catalytic oxidation at 680 °C and NDIR detection method with user friendly design. The heart of the TOC-L instrument is the ISP (integrated sample pretreatment system), consisting of an 8-port valve and a syringe with sparging gas connection. The ISP module allows automatic dilution which is extremely useful for various applications. The measuring range for TOC determination is increased up to 30,000 mg/L. Samples contaminated with high salt can be diluted automatically. Where the TOC concentration does not allow a dilution, the new high salt kit can handle these samples. This increases the lifetime of the catalyst and combustion tube while reducing maintenance time and running costs of the TOC analyzer. For simultaneous TOC and Total Nitrogen analysis, the TNM-L system can be added without increasing the size of the footprint. Highly sensitive chemiluminescence detection offers a measuring range between 5 µg/L and 10,000 mg/L.
TOC-Control L Software, the state-of-the-art software for PC control, combines new features with easy-to-use operation. The clear layout of the sample window editor offers users “at-a-glance” access to all relevant information. Proven functions such as control cards, validation table and export functions are included.
For further details please visit www.shimadzu.eu
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
