HPLC 2009 Wednesday Afternoon
The last of our HPLC 2009 show dailies
To begin the afternoon Robert Kennedy, Fritz Emi and Paola Dugo will present tutorials on Process Scale Batch and Continuous Chromatographic Separations, Quality by Design and Principles and Applications of Speciation Analysis.
The tutorials will then be followed by the afternoon’s sessions on Monoliths, Quality by Design and LC–MS and CE–MS by Frantisek Svek, Fritz Erni and Gerard Hopfgartner.
Nobua Tanaka discusses high efficiency monolithic silica capillary columns in the first lecture of the Monoliths sessions. Fabrice Gritti then discusses mass transfer in monolithic columns with different average pore sizes followed by a lecture by Karin Cabrera on the influence of the macro- and mesopore size on the performance of monolithic HPLC columns. Emily Hilder closes the session with a talk on improving the performance of polymer monoliths to separate small molecules.
The Quality by Design sessions begins with a keynote lecture on QbD and analytical methods for European companies by Mathias Pohl followed by a talk on the impact of the new ICH quality paradigm on the European Pharmacopoeia. Christoph Meyer gives his views on QbD for HPLC from the perspective of the pharmaceutical industry and Imre Molnar reveals his approach to QbD involving HPLC method development.
The session on LC–MS and CE–MS starts with Yehia Mechref on multiple reaction monitoring LC–MS for the monosacharride compositional analysis of glycoproteins followed by a lecture on ultrahigh-resolution MS in fast LC coupling for the analysis of complex mixtures. Pierangela Palma discusses matrix effects when using LC–MS with direct EI interface and Julian Schappler closes the session with a talk on blood doping with HBOC using CE-UV–ESI-TOF-MS.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
