HPLC 2009 Tuesday Afternoon
The Tuesday afternoon sessions of HPLC 2009
Bruno Bolinger, Guenther Bonn and Rainer Bischoff will present tutorials on Validating Analytical Methods, Modern Stationary Phase Technologies and Biomarker Discovery and Validation.
The Tuesday afternoon sessions chaired by Michael Lammerhoffer, Guenther Bonn and Marja Lisa Riekkola on Column Technology, Industrial Analysis and Biopharmaceutical and Biomedical Analysis will then begin.
Uwe Neue describes a new world of UHPLC and HILIC application in the first Column Technology lecture. This will be followed by Judi Abia on radial heterogeneity of some analytical columns used in HPLC. Andrew Shalliker will discuss the importance of column bed heterogeneity and viscosity contrast for solute elution profiles. Christian Huck will close this session by describing the importance of the simultaneous determination of physical and chemical parameters of porous polymers with a combined use of Fourier-Transform near infrared diffuse reflection spectroscopy with multivariate techniques.
The Industrial Analysis lectures comprise John Frenz on the challenges in the manufacture and characterization of inactivated yeast therapeutic vaccines, Franka Kalman on the use of molecular CE to develop robust and reliable industrial biopharmaceutical test methods, Dell Farnan on multi-product charge heterogeneity profiling of recombinant monoclonal antibodies using PH gradient ion exchange chromatography and G. Choudray on the analytical characterization of inhalable powders.
The Biopharmaceutical and Biomedical Analysis session starts with Rui Zhao on the characterization of human plasma intact peptides and LMW proteins and their modifications using HELC–FT-MS–MS–UStags, followed by Rayane Mohamed on a comprehensive analytical strategy for the structural identification of biomarkers in biofluids. Melina Quaglia will describe work on LC–MS for absolute protein quantification and Djuro Josic closes with a seminar on proteomics as a tool for the optimization of human plasma-derived therapeutic proteins.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
