Gilson Product Profile
IT’S YOUR CHEMISTRY ... SIMPLIFIED
Gilson is pleased to announce the expansion of its range of HPLC purification systems with the launch of a new Gilson LC/MS system. This system provides researchers with the ability to use the specificity of mass spectrometry to increase the efficiency of their purification processes.
The addition of a mass spectrometer allows mass targeted purification, and thus reduces the number of collected fractions to be processed, while providing information on the mass of purified compounds.
Gilson has developed the first easy-to-use, practical mass-based purification system.
The LC/MS Purification System from Gilson features a world class performing MS detector combined with Gilson's industry leading preparative HPLC system to produce a truly unique and usable mass targeted purification system.
The Gilson LC/MS system has been designed with the user in mind; it is easy to use and has been developed around the existing Trilution LC software dedicated to preparative chromatography and the GX-271/GX-281 injection/collection platforms recognized for their robustness and flexibility.
You do not need to be an expert in mass spectrometry technology to add this feature to your purification system!
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.