Chromatography and Mass Spectrometry for the Analysis of Pharmaceuticals and Biologics
This Monday morning session will be presided over by Arindam Roy of Novartis Consumer Health.
Session 290
Room 123
This Monday morning session will be presided over by Arindam Roy of Novartis Consumer Health. It will show how leading scientists use chromatography and mass spectrometry in the development of both the traditional pharmaceuticals — where the active ingredient is a small molecule — and biopharmaceuticals — where the active ingredient is a large-molecule protein or monoclonal antibody (mAb).
The first two talks will cover small-molecule pharmaceuticals. David K. Robbins of Eli Lilly will discuss the use of these methods for the analysis of trace impurities of toxicological concern. Next, Roy will talk about developing, validating, and transferring methods for quality control of drug products.
The next three presentations will cover large molecules. Taylor Yonghua Zhang of Genentech will address how to decipher unknown peaks in HPLC for the analysis of mAbs. The characterization of protein therapeutics by mass spectrometry will be the subject of the following presentation, by Li Tao of Bristol-Myers Squibb. To close the session, Isabel Feuerstein of Sandoz will discuss the extensive characterization of biosimilars using chromatography and mass spectrometry.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
