LCGC is planning to publish the next issue of The Application Notebook special supplement in December. The publication will include vendor application notes that describe techniques and applications of all forms of chromatography and capillary electrophoresis that are of immediate interest to users in industry, academia, and government. If your company is interested in participating in these special supplements, contact:
LCGC is planning to publish the next issue of The Application Notebook special supplement in December. The publication will include vendor application notes that describe techniques and applications of all forms of chromatography and capillary electrophoresis that are of immediate interest to users in industry, academia, and government. If your company is interested in participating in these special supplements, contact:
Michael J. Tessalone, Group Publisher,
(732) 346-3016
Edward Fantuzzi, Associate Publisher,
(732) 346-3015
Stephanie Shaffer, East Coast Sales Manager,
(508) 481-5885
It is important that each company's material fit within the allotted space. The editors cannot be responsible for substantial editing or handling of application notes that deviate from the following guidelines:
Each application note page should be no more than 500 words in length and should follow the following format.
References
All text will be published in accordance with LCGC's style to maintain uniformity throughout the book. It also will be checked for grammatical accuracy, although the content will not be edited. Text should be sent in electronic format, preferably using Microsoft Word.
Refer to photographs, line drawings, and graphs in the text using arabic numerals in consecutive order (Figure 1, etc.). Company logos, line drawings, graphs, and charts must be professionally rendered and submitted as .TIF or .EPS files with a minimum resolution of 300 dpi. Lines of chromatograms must be heavy enough to remain legible after reduction. Provide peak labels and identification. Provide figure captions as part of the text, each identified by its proper number and title. If you wish to submit a figure or chromatogram, please follow the format of the sample provided below.
Figure 1: Chromatograms obtained using the conditions under which the ion suppression problem was originally discovered. The ion suppression trace is shown on the bottom. Column: 75 mm à 4.6 mm ODS-3; mobile-phase A: 0.05% heptafluorobutyric acid in water; mobile-phase B: 0.05% heptafluorobutyric acid in acetonitrile; gradient: 5â30% B in 4 min. Peaks: 1 = metabolite, 2 = internal standard, 3 = parent drug.
Each table should be typed as part of the main text document. Refer to tables in the text by roman numerals in consecutive order (Table I, etc.). Every table and each column within the table must have an appropriate heading. Table number and title must be placed in a continuous heading above the data presented. If you wish to submit a table, please follow the format of the sample provided below.
Table I: Factor levels used in the designs
Literature citations must be indicated by arabic numerals in parentheses. List cited references at the end in the order of their appearance. Use the following format for references:
(1) T.L. Einmann and C. Champaign, Science 387, 922–930 (1981).
The deadline for submitting application notes for the December issue of The Application Notebook is:
October 21, 2011
This opportunity is limited to advertisers in LCGC North America.
For more information, contact: Mike Tessalone at (732) 346-3016, Ed Fantuzzi at (732) 346-3015, or Stephanie Shaffer at (508) 481-5885.
SEC-MALS of Antibody Therapeutics—A Robust Method for In-Depth Sample Characterization
June 1st 2022Monoclonal antibodies (mAbs) are effective therapeutics for cancers, auto-immune diseases, viral infections, and other diseases. Recent developments in antibody therapeutics aim to add more specific binding regions (bi- and multi-specificity) to increase their effectiveness and/or to downsize the molecule to the specific binding regions (for example, scFv or Fab fragment) to achieve better penetration of the tissue. As the molecule gets more complex, the possible high and low molecular weight (H/LMW) impurities become more complex, too. In order to accurately analyze the various species, more advanced detection than ultraviolet (UV) is required to characterize a mAb sample.