Two tutorial sessions take place in parallel from 5:00 to 6:30 pm today. Topics include mass spectrometry in the biopharmaceutical industry; machine learning in mass spectrometry; mass spectrometry in natural product research; and more.
In Tutorial Session I, from 5:00 to 5:45 in Hall A, Iain D.G. Campuzano of Amgen Research will discuss mass spectrometry in the biopharmaceutical industry, offering a look at the technique used for small molecules, multi-specific antibodies, and beyond. The talk will include specific examples of where and how mass spectrometry and associated hyphenated chromatographic techniques, as well as processing and software solutions, are used during specific stages of therapeutic drug research, progression, selection, and development.
Later in Session I, from 5:45 to 6:30 in Hall A, Randy Julian of Indigo BioAutomation will discuss machine learning in mass spectrometry. The presentation will introduce three fundamental approaches to machine learning: unsupervised, supervised, and reinforcement learning.
Tutorial Session II, taking place in L100 from 5:00 to 6:30, features Laura Sanchez of the University of California, Santa Cruz, and Ryan Julian of the University of California, Riverside, each presenting a talk. Sanchez will lead with a discussion about mass spectrometry in natural product research. The talk will chronical the ways in which mass spectrometry has been used in natural product discovery research programs and its evolution to become a mainstay technology for the natural products field. Julian will present a talk titled “Radical Chemistry for Biomolecular Identification: From Fundamentals to Applications.” This tutorial will describe how to make radicals, how they mediate dissociation, and how this chemistry can be translated to provide novel information about a wide range of biomolecular species.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.