Double your discovery: The Agilent 1260 Infinity Hybrid SFC/UHPLC System packs two orthogonal separation modes into one instrument, bringing you more information from a single automated sequence.
The new Agilent 1260 Infinity Hybrid SFC/UHPLC System packs two orthogonal separation modes into one instrument, bringing you more information from a single automated sequence. Switching between the two techniques SFC and UHPLC has never been so easy. A software-controlled valve allows you to alternate smoothly and reproducibly between SFC and UHPLC methods within a single analysis sequence – no hardware changes are needed and equilibration times are minimal.
The Agilent 1260 Infinity Hybrid SFC/UHPLC system is the only SFC system available that offers true UHPLC capability with a 600 bar power range. It also provides the broadest price/performance range of any SFC system available. Whether you want to upgrade your current Agilent 1100 or 1200 Series system, or start with the Agilent 1260 Infinity Analytical SFC system as a dedicated instrument, you can easily adapt your system to create a hybrid unit and then further expand your detection capabilities with an Agilent evaporative light scattering detector or a mass spectrometer from Agilent’s extensive LC/MS portfolio.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.