Liquid Chromatography (LC/HPLC)

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

To honor the 2025 International Day of Women and Girls in Science, the editors of LCGC share highlights from our series done in collaboration with Females in Mass Spectrometry (FeMS) group.

In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used for LC methods involving UV absorbance detection.

ACD/Labs recently released their 2025 Structure Elucidation & Verification Report, discussing how informatics trends have shifted since 2022.

Labomatic Instruments and Knauer recently announced a new strategic cooperative relationship to offer their instrument portfolios to each other’s customer bases.

Here is some of the most popular content posted on LCGC International this week.

You're invited to publicize your 2024–2025 new product introductions in LCGC. Here's how to get your products included.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.

University of Turin scientists developed a UHPLC–PDA-MS/MS-based method for quantifying plant-specialized metabolites for determining the quality of medicinal and aromatic plants.

Paris-Saclay University scientists used hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS) and inductively coupled plasma mass spectrometry (ICP-MS) to assess thorium’s interaction with peptides.

In this edition of The LCGC Blog, Jonathan Shackman discusses what factors to consider when choosing a mobile phase for liquid chromatography (LC) procedures.

New methods have been developed to determine polar emerging contaminants with hydrophilic interaction liquid chromatography (HILIC) techniques.

University College London scientists recently created a new technique for selecting two-dimensional liquid chromatography (2D-LC) columns.

Scientists from the Henan Academy of Sciences recently developed a new technique for the determination of hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) from urine.

A new process for tracking targeted and non-targeted fluorinated residuals using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) has been created.

An investigation into fluoroelastomer watch bands has revealed high levels of perfluorohexanoic acid (PFHxA), a short-chain per- and polyfluoroalkyl substance (PFAS). LCGC International spoke to Professor Graham Peaslee from the University of Notre Dame about his team’s study using liquid chromatography tandem mass spectrometry (LC–MS/MS) and PFHxA's potential for dermal absorption, and the subsequent environmental and health impacts.

Scientists from the National Institutes for Food and Drug Control have characterized antibody-drug conjugates (ADCs) using various mass spectrometry (MS)-based techniques.

“Forever chemicals” per- and polyfluoroalkyl substances (PFAS) have been found in smartwatch and fitness bands and analyzed using liquid chromatography tandem mass spectrometry (LC–MS/MS) and direct total oxidative precursor (dTOP) assay.

Here is some of the most popular content posted on LCGC International this week.

Scientists recently studied how different factors affect antisense oligonucleotides (ASOs) under hydrophilic interaction liquid chromatography (HILIC) conditions.

Using ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), China Pharmaceutical University scientists developed a new method for analyzing compounds found in wastewater.

Here is some of the most popular content posted on LCGC International this week.

University of Valencia scientists recently developed a method using solid-phase extraction (SPE) followed by high-performance liquid chromatography coupled to high-resolution mass spectrometry (HPLC–HRMS/MS) for detecting microplastics and other harmful substances in textiles.

Spanish scientists recently tested flow injection analysis–mass spectrometry (FIA–MS) and its effectiveness in detecting fraudulent substances in Coleus forskohlii food supplements.

Here is some of the most popular content posted on LCGC International this week.

Jiangsu Police Institute scientists recently created a solid-phase microextraction (SPME)-based method for determining amphetamine-type stimulants.

University of Oslo scientists combined electromembrane extraction (EME) and flow injection-MS/MS (FI–MS/MS) to determine polar endogeneous metabolites in human plasma.

In this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.

In the first LCGC Blog of 2025, Caitlin Cain of the University of Michigan highlights the divide between gas and liquid chromatographers, and why both types of techniques should be in the same conversations.

In 2024, we launched a content series, covered major conferences, presented prestigious awards, and continued our monthly Analytically Speaking podcasts. Below, you'll find a selection of the most popular content from LCGC International over the past year.