Joe Glajch on Biosimilars, Part 3: Strategies for Demonstrating Similarity of Biologics
December 1st 2015How fully can we characterize a biopharmaceutical? Strategies for demonstrating similarity, including statistical approaches. What the first US approval of a biosimilar tells us about the FDA's thinking.
Chromate in Toys, Leather, and Potable Water Metrohm AG
December 1st 2015Generally speaking, chromate - Cr(VI) - is classified as allergenic, carcinogenic, and extremely toxic and is subject to strict monitoring. Cr(VI) can occur in various concentrations in different areas, for example, drinking water, toys, or textile and leather products. Metrohm has developed ion chromatographic determination methods for determining Cr(VI) in various concentration ranges (ng/L to mg/L) with inline sample preparation techniques for various matrices. The method can be almost entirely automated. In the following application note, we present the analysis of hexavalent chromium in toys, leather, and drinking water.
Quick and Convenient Comparison of Curry Powders Using Direct Thermal Desorption with GC-MS Analysis
December 1st 2015Herbs and spices are used in many food preparations, and identifying the differences between samples is of particular interest to manufacturers, both for ongoing quality control and to compare their products against competitors. However, the volatile organic compound (VOC) profiles of such samples often differ in the relative abundance of key components, and these differences can be difficult to assess by traditional methods such as solvent extraction, equilibrium headspace, or solid-phase microextraction (SPME).
Lab Water Hints and Tips Part 2: Optimal Handling of Purified Water
November 30th 2015Following on our previous Dedicated Dialogue which discussed lab water contaminants and purification technologies, this Dedicated Dialogue will consider specific ways to handle and manage a lab water purification system and the product water from these systems in order to ensure consistent and reliable results.
Practical Applications of Asymmetrical Flow Field-Flow Fractionation (AF4): A Review
November 30th 2015Characterization of macromolecules and colloids is an area of considerable interest. Asymmetrical flow field-flow fractionation (AF4) has become a well-established method, but many potential users possess limited knowledge of its capabilities, or how it can provide additional information or serve as validation to the traditional analytical techniques. This review article highlights several practical applications where AF4 should be given special consideration, and discusses benefits and drawbacks of the different methods.
Sensitive Analysis of the Lactose Content of Lactose‑Free Labelled Products Using HPAEC-PAD
November 30th 2015The market for lactose-free products is growing rapidly and constantly and Europe is a worldwide leader in the lactose‑free market. Between 2012 and 2016 the sales of lactose-free products are expected to increase by 75%.
Lab Water Hints and Tips Part 2: Optimal Handling of Purified Water
November 23rd 2015Following on our previous Dedicated Dialogue which discussed lab water contaminants and purification technologies, this Dedicated Dialogue will consider specific ways to handle and manage a lab water purification system and the product water from these systems in order to ensure consistent and reliable results.
Off-Line NMR Improves Traditional Chinese Medicine Analysis
November 23rd 2015Researchers at Zhejiang University, China, have developed a new method combining liquid chromatography-mass spectrometry (LC-MS) and off-line nuclear magnetic resonance (NMR) to analyze the constituents within traditional Chinese medicines (TCMs).
Screening Procedure for “Non Banned” Drugs
November 23rd 2015A new screening procedure has been developed for the detection of common “non banned” drugs used by athletes. The method targets multiple pharmacologically active compounds by liquid chromatography-electrospray ionization coupled to tandem mass spectrometry (LC-ESI-MS-MS).