Looking at the Past to Understand the Future: Soxhlet Extraction
August 1st 2019To better understand modern sample preparation techniques-such as ultrasound-assisted extraction, microwave-assisted extraction, and pressurized solvent extraction-we should look at the lessons these methods took from Soxhlet extraction.
HILIC to the Rescue: Pharmaceutical Development Case Examples
August 1st 2019HILIC has rapidly evolved into a practical technique. For analyzing highly polar compounds, HILIC can be far more straightforward than GC or reversed-phase LC with derivatization, and can lead to a simpler final method with robustness comparable to that of reversed-phase LC.
Data Integrity Focus, Part VII: A Data Life Cycle for Chromatography
August 1st 2019Several regulatory data integrity guidance documents require that laboratories understand the data life cycle of their processes, but provide only vague definitions of what a data life cycle is. Here is a practical interpretation.
Pass the Salt: Evolution of Coupling Ion-Exchange Separations and Mass Spectrometry
August 1st 2019Direct coupling of ion-exchange separations to mass spectrometric (MS) detection is increasingly being used for analyses of molecules ranging from organic acids to proteins. These approaches leverage both the exquisite selectivity of the ion-exchange mode for charge-based separation, and the tremendous power of mass spectrometry for identification of unknowns and trace-level quantitation.
Modern HPLC Pumps: Perspectives, Principles, and Practices
August 1st 2019This instalment is the first of a series of four white papers on high performance liquid chromatography (HPLC) modules (pump, autosampler, UV detector, and chromatography data system) to be published in 2019. This instalment provides an overview for analytical-scale HPLC pumps, including their requirements, modern designs, operating principles, trends, and best practices for trouble-free operation.
The LCGC Blog: Is Hydrogen the Only Viable Gas Chromatography Carrier Gas for the Long-Term?
July 16th 2019As I receive reports from clients in Europe and the United States that helium prices are once again increasing, and warnings are being given regarding yet another laboratory-grade helium shortage, my thoughts turn once again to the use of hydrogen as an alternative carrier-gas for gas chromatography.
Gulf Coast Conference Continues to Transform the Analytical World
July 16th 2019The Gulf Coast Conference (GCC) is held in Galveston annually. For the past 50+ years, this gathering of international scientists has blazed a trail for analytical needs and innovations for the refining and petrochemical industries.
Understanding Data Integrity in Your Laboratory Operations
July 15th 2019Data Integrity has become a critical issue in the pharma industry as a result of increased regulatory scrutiny stemming from Data Integrity-related violations. This ebook provides insight on a variety of important topics within this space.
Meeting Review: Latest Advances in the Analysis of Complex Environmental Matrices, 2019
July 10th 2019A biennial meeting jointly organized by the Environmental Chemistry Group, Separation Sciences Group, and the Water Science Forum, and discussing the latest advances in the analysis of complex environmental matrices, is now in its eighth year. The most recent iteration of the event occurred on Friday 22 February 2019 in the Science Suite, Royal Society of Chemistry, Burlington House, in London, UK. This meeting review offers an overview of what is happening in the industry.
The 30th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2019)
July 10th 2019A preview of the upcoming 30th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2019), which is due to be held on 15–18 September 2019 at the Convention Centre of The Dan Panorama Hotel in Tel Aviv, Israel.
A Whole Lot of Data Going On Book Review: Data Integrity and Data Governance by R.D. McDowall
July 10th 2019R.D. McDowall has written an excellent book on data integrity and data governance. Those who need to understand what this is should read the book and follow his advice. He has included both what the regulations and regulators say and what we need to do to be in compliance. This is a scalable approach with enhancements for larger items and shortcuts for smaller items, with numerous examples throughout the book.